• Publications
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The effect of Histomonas meleagridis on the development of Eimeria tenella.
  • L. Chappel
  • Biology, Medicine
  • The Journal of parasitology
  • 1 August 1973
TLDR
The present investigation examined the effect of H. meleagridis on the development of E. tenella, a disease syndrome of coccidiosis resulting from a single species infection differs from infections produced by mixed species or by coccidia plus other intestinal protozoa or helminths. Expand
Using the HmL1 strain of Histomonas meleagridis in evaluating chemotherapeutants in chicks.
  • L. Chappel
  • Biology, Medicine
  • Avian diseases
  • 1 October 1975
TLDR
Ten-day-old White Leghorn cockerels were inoculated per cloaca with 500,000 culture forms of the HmL1 strain of Histomonas meleagridis, demonstrating the utility of this virulent strain in chemotherapy studies. Expand
Anticoccidial efficacy of semduramicin. 2. Evaluation against field isolates including comparisons with salinomycin, maduramicin, and monensin in battery tests.
TLDR
The data indicate that semduramicin at 25 ppm is well tolerated in broilers and possesses broad spectrum anticoccidial activity. Expand
Field trials comparing salinomycin (Coxistac), monensin, and lasalocid in the control of coccidiosis in broilers.
TLDR
Salinomycin and monensin had equivalent lesion control which was statistically superior (P) and Salinomycin a broad spectrum ionophore anticoccidial was evaluated for toleration and efficacy at 60 ppm in the feed of broiler reared to market weight under floor pen conditions. Expand
The site of action of a broad-spectrum aryltriazine anticoccidial, CP-25,415.
Anticoccidial efficacy of a new polyether antibiotic, salinomycin, in comparison to monensin and lasalocid in battery trials.
TLDR
Broiler chicks were given salinomycin in the feed at levels of 30 and 60 ppm in battery trials to measure the efficacy against six major species of Eimeria to determine the relative potency of each anticoccidial agent. Expand
The site of action of the anticoccidial salinomycin (Coxistac).
  • L. Chappel
  • Biology, Medicine
  • The Journal of parasitology
  • 1 February 1979
TLDR
Activity against asexual stages was so complete that only a limited number of parasites survived to form gamonts, and oocyst shedding was reduced by 80--90% relative to controls, and salinomycin had no effect upon rate of oocySt sporulation. Expand
Anticoccidial efficacy of semduramicin. 1. Evaluation against field isolates by dose titration in battery tests.
TLDR
Semduramicin (AVIAX), a novel polyether ionophore, was titrated in a series of five battery tests at 20, 25, and 30 ppm in feed to determine the optimum level for use and significantly reduced coccidiosis mortality and lesion scores. Expand
Anticoccidial derivatives of 6-azauracil. 5. Potentiation by benzophenone side chains.
Attachment of p-benzophenone side chains at N1 was found to be one of the most effective modifications for enhancing the potency of 6-azauracil against a broad spectrum of coccidia in chickens.Expand
CP-61,405, a novel polycyclic pyrrolether antibiotic produced byStreptomyces routienii Huang sp. nov.
TLDR
CP-61,405 was co-produced with the polycyclic ether antibiotics salinomycin and epi-17-deoxy-(0–8)-salinomycin, and exhibited activity in vitro against gram-positive and anaerobic bacteria, efficacy against poultry coccidia and stimulation in vitro of propionic acid production. Expand
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