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Mapping metals in Parkinson's and normal brain using rapid-scanning x-ray fluorescence.
TLDR
RS-XRF was validated by mapping and quantifying iron, zinc and copper in brain slices from Parkinson's disease and unaffected subjects and holds great promise to reveal metal pathologies associated with PD and other neurodegenerative diseases as well as diseases of metal metabolism.
Memory and survival after microbeam radiation therapy.
Synchrotron X-ray Fluorescence Reveals Abnormal Metal Distributions in Brain and Spinal Cord in Spinocerebellar Ataxia: A Case Report
TLDR
It is suggested that if these findings are generally true of at least some cases of SCA, not only iron but also copper and zinc should be considered as possible therapeutic targets.
Three dimensional mapping of strontium in bone by dual energy K-edge subtraction imaging.
TLDR
The ability of synchrotron radiation dual energy K-edge subtraction (KES) imaging to map the 3D distribution of elemental strontium within rat vertebral samples is demonstrated, which has great potential for ex vivo analysis of preclinical models and human tissue samples.
Biodistribution of strontium and barium in the developing and mature skeleton of rats
TLDR
This study displayed spatial co-localization of barium and strontium in bone for the first time and used it to study the pathological changes in animal models of bone disease and the effects of pharmaceutical compounds on bone micro-architecture and bone remodeling in high spatial sensitivity and precision.
Nebulized hypertonic saline triggers nervous system-mediated active liquid secretion in cystic fibrosis swine trachea
TLDR
The results indicated that HTS-triggered ASL secretion is partially mediated by the stimulation of airway neurons and the subsequent activation of active epithelia secretion; osmosis accounts for only ~50% of the effect.
Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens
TLDR
It is shown that exposure to bacteria triggers secretion in wild-type but not in pig models of cystic fibrosis, suggesting an impaired response to pathogens contributes to infection.
Diffraction-enhanced imaging of the rat spine.
TLDR
This study represents the first use of DEI, a novel imaging modality, to image the vertebral column, and provides excellent anatomic detail with superior contrast and visualization of both bone and soft tissue when compared with conventional radiography.
Diffraction-enhanced imaging of a porcine eye.
TLDR
Diffraction-enhanced imaging represents a novel, high-resolution imaging technique that has excellent characterization of ocular anatomy and will be undertaken to study cataract and choroidal tumors and to examine ocular surface structures, such as the extraocular muscle insertions, more closely.
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