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Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits.
- Sarot Cheenpracha, E. Park, +4 authors L. Chang
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 September 2010
Bioassay-guided isolation and purification of the ethyl acetate extract of Moringa oleifera fruits yielded three new phenolic glycosides that are reported to have potent NO-inhibitory activity and reduced LPS-mediated iNOS expression. Expand
Natural inhibitors of carcinogenesis.
Based on this large pool of potential cancer chemopreventive compounds, structure-activity relationships are discussed in terms of the quinone reductase induction ability of flavonoids and withanolides and the cyclooxygenase-1 and -2 inhibitory activities of flavanones, flavones and stilbenoids. Expand
Covalent Trimers of the Internal N-terminal Trimeric Coiled-coil of gp41 and Antibodies Directed against Them Are Potent Inhibitors of HIV Envelope-mediated Cell Fusion*
- J. Louis, Issa Nesheiwat, L. Chang, G. Clore, C. Bewley
- Biology, Medicine
- Journal of Biological Chemistry
- 30 May 2003
Results indicate that N35CCG-N13 is a potential anti-HIV therapeutic agent and represents a suitable immunogen for the generation of neutralizing monoclonal antibodies targeted to the internal trimeric coiled-coil of HIV-1 gp41. Expand
Crambescidin 826 and dehydrocrambine A: new polycyclic guanidine alkaloids from the marine sponge Monanchora sp. that inhibit HIV-1 fusion.
Two new polycyclic guanidine alkaloids were isolated from the marine sponge Monanchora sp. Expand
Inhibition of Lipopolysaccharide-Induced Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression by 4-[(2′-O-acetyl-α-L-Rhamnosyloxy)Benzyl]Isothiocyanate from Moringa oleifera
- E. Park, Sarot Cheenpracha, L. Chang, T. Kondratyuk, J. Pezzuto
- Biology, Medicine
- Nutrition and cancer
- 1 August 2011
RBITC inhibited phosphorylation of extracellular signal-regulated kinase and stress-activated protein kinase, as well as ubiquitin-dependent degradation of inhibitor κBα (IκBα). Expand
Bioactive polybrominated diphenyl ethers from the marine sponge Dysidea sp.
- H. Zhang, Andrew Skildum, Emily Stromquist, T. Rose-Hellekant, L. Chang
- Biology, Medicine
- Journal of natural products
- 17 January 2008
A new polybrominated diphenyl ether and eight known compounds isolated from the crude organic extract of the marine sponge Dysidea sp. Expand
Potent inhibition of HIV-1 fusion by cyanovirin-N requires only a single high affinity carbohydrate binding site: characterization of low affinity carbohydrate binding site knockout mutants.
It is interpreted as indicating that the low affinity carbohydrate binding site of CVN is not necessary for high affinity binding to gp120, and HIV-1 fusion can therefore be blocked by monovalent protein-carbohydrate interactions. Expand
Bioactive constituents of the seeds of Brucea javanica.
A new quassinoid, yadanziolide S (1), was isolated from the seeds of the traditional Chinese medicinal herb, Brucea javanica, along with ten known compounds, flazin, bruceine D, yadanziolide B,… Expand
Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318
Investigation of a microbial fermentation organic extract of Penicillium sp. H9318 led to the isolation of a new isoquinolinone alkaloid, (5S)-3,4,5,7-tetramethyl-5,8-dihydroxyl-6(5H)-isoquinolinone… Expand
Butterfly cluster like lamellar BiOBr/TiO2 nanocomposite for enhanced sunlight photocatalytic mineralization of aqueous ciprofloxacin.
- J. Rashid, Ammara Abbas, +7 authors M. Barakat
- Materials Science, Medicine
- The Science of the total environment
- 15 May 2019
The present study for the first time reports facile in-situ room temperature synthesis of butterfly cluster like lamellar BiOBr deposited over TiO2 nanoparticles for photocatalytic breakdown of… Expand