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Anti-nuclear, anti-neutrophil cytoplasmic and anti-glomerular basement membrane antibodies in HIV-infected individuals.
Many autoantibodies have been described in HIV-infected individuals. We have examined the incidence, associations and prognostic significance of anti-nuclear antibodies (ANA), anti-neutrophilExpand
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Decay of Female Sexual Behavior Under Parthenogenesis
A laboratory strain of Drosophila mercatorum has existed for 20 years without males and therefore without natural selection operating to maintain the genetic basis of female mating behavior. TheExpand
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Autoantibodies and target antigens in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides
In this study of antineutrophil cytoplasmic antibody (ANCA)-associated diseases, we determined the prevalence of other autoantibodies and the antigen specificities of ANCA. ANA were common, occurringExpand
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Myelodysplasia, vasculitis and anti-neutrophil cytoplasm antibodies.
A cutaneous or systemic vasculitis occurs in myelodysplasia as well as in myeloproliferative and lymphoproliferative disorders. The most common lesion is a leucocytoclastic vasculitis, withExpand
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Anti-neutrophil cytoplasmic antibodies (ANCA) in myelodysplasia and other haematological disorders.
BACKGROUND Anti-neutrophil cytoplasmic antibodies (ANCA) are typically associated with small vessel vasculitides. They are also found in situations where other autoantibodies are common, sometimesExpand
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Epitope mapping of anti‐proteinase 3 and anti‐myeloperoxidase antibodies
Anti‐proteinase 3 (PR3) and anti‐myeloperoxidase (MPO) autoantibodies are present in many patients with Wegener's granulomatosis (WG) and microscopic polyarteritis. The aim of this study was toExpand
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Anti‐proteinase 3 antibodies, their characterization and disease associations
Anti‐proteinase 3 antibodies are a subgroup of anti‐neutrophil cytoplasmic antibodies (ANCA), and we have established an ELISA for their detection using high performance liquid chromatograhyExpand
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Preparation/analysis of chromatin replicated in vivo and in isolated nuclei.
This article outlined biochemical methodologies for the labeling, detection, and analysis of newly replicated and newly assembled nucleosomes. The isolation of specific vertebrate factors that may beExpand
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α1‐Antitrypsin deficiency and anti‐proteinase 3 antibodies in anti‐neutrophil cytoplasmic antibody (ANCA)‐associated systemic vasculitis
α1‐antitrypsin (α1‐AT) is a naturally occurring inhibitor of proteinase 3 (PR3) and elastase, two of the target antigens of anti‐neutrophil cytoplasmic antibodies (ANCA). An increased incidence ofExpand
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Structural characterization of γ1-heavy chain disease protein BAZ: Heterogeneity of the constant region
Abstract γ 1 -heavy chain disease protein (HCD) BAZ has a molecular weight of 60,000 daltons and contains a substantial quantity of carbohydrate (14%) in comparison to normal γ-chains which isExpand
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