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Structure of zebra fish HIUase: insights into evolution of an enzyme to a hormone transporter.
The crystal structure of zebra fish HIUase in two different crystal forms is reported, showing a highly conserved scaffold, harbouring distinct functional sites located in the same regions of the two vertebrate proteins. Expand
The ATP‐Binding Site of Protein Kinase CK2 Holds a Positive Electrostatic Area and Conserved Water Molecules
The crystal structure of three new complexes with tetrabromobenzimidazole derivatives that display Ki values between 0.15 and 0.30 μM are determined and revealed the presence of some highly conserved water molecules in the ATP‐binding site. Expand
DJ-1 Is a Copper Chaperone Acting on SOD1 Activation*
Alteration of the coordination geometry of the copper ion in DJ-1 may be correlated to the physiological role of the protein, to a potential failure in metal transfer to SOD1, and to successive implications in neurodegenerative etiopathogenesis. Expand
Crystal structure of alkyl hydroperoxide-reductase (AhpC) from Helicobacter pylori.
The AhpC protein from H. pylori, a thioredoxin (Trx)-dependent alkyl hydroperoxide-reductase, is a member of the ubiquitous 2-Cys peroxiredoxins family (2-Cys Prxs), a group of thiol-specificExpand
The Helicobacter pylori CagD (HP0545, Cag24) protein is essential for CagA translocation and maximal induction of interleukin-8 secretion.
The results suggest that CagD may serve as a unique multifunctional component of the T4SS that may be involved in CagA secretion at the inner membrane and may localize outside the bacteria to promote additional effects on the host cell. Expand
Structural and functional aspects of the Helicobacter pylori secretome.
Proteins secreted by Helicobacter pylori (H. pylori), an important human pathogen responsible for severe gastric diseases, are reviewed from the point of view of their biochemical characterization,Expand
Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors
TTR and TTR bind by x‐ray crystallography (View interaction) and it is shown that TTR binds to TTR more strongly than either TTR or TTR can bind to X‐ray diffraction. Expand
Logical Identification of an Allantoinase Analog (puuE) Recruited from Polysaccharide Deacetylases*
It is shown that an alternative allantoinase gene (puuE) can be precisely identified by analyzing its logic relationship with three other genes of the pathway by providing a structural rationale for the shifting of substrate specificity that occurred during evolution. Expand
Crystal structure of sarcoplasmic reticulum Ca2+-ATPase (SERCA) from bovine muscle.
The crystal structure of the bovine enzyme is described, crystallized in the E1 conformation and determined at 2.9Å resolution, and the overall molecular model is very similar to that of the rabbit enzyme, as expected by the high amino acid sequence identity. Expand
Potential pathogenic role of beta-amyloid(1-42)-aluminum complex in Alzheimer's disease.
A significant involvement of Al is shown in promoting a specific amyloid aggregation, which is able to produce marked toxic effects on neuroblastoma cells, as clearly demonstrated for the first time in this study. Expand