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Decreased Adrenocorticotropic Hormone and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment
TLDR
In adults without diagnosable psychopathology, childhood maltreatment is associated with diminished HPA axis response to a psychosocial stressor. Expand
Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
TLDR
Data suggest that TRP depletion results in substantial declines in central 5-HT turnover, which is similar to that observed in healthy adult subjects after a one-day low-TRP diet and a TRP-free amino acid drink. Expand
Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression
TLDR
Deep brain stimulation of the VC/VS offers promise for the treatment of refractory major depression. Expand
Effects of 12 Months of Vagus Nerve Stimulation in Treatment-Resistant Depression: A Naturalistic Study
TLDR
These 1-year open trial data found VNS to be well tolerated, suggesting a potential long-term, growing benefit in treatment-resistant depression, albeit in the context of changes in depression treatments. Expand
Telomeres and Early-Life Stress: An Overview
TLDR
Emerging work suggests a robust, and perhaps dose-dependent, relationship with early-life stress, which presents new opportunities to reconceptualize the complex relationships between experience, physical and psychiatric disease, and aging. Expand
Association between Plasma IL-6 Response to Acute Stress and Early-Life Adversity in Healthy Adults
TLDR
Plasma IL-6 response to the Trier Social Stress Test (TSST) was examined in 69 healthy adult subjects without depression or post-traumatic stress disorder to further elucidate the relationship between childhood maltreatment and pro-inflammatory cytokine production. Expand
Childhood Adversity and Epigenetic Modulation of the Leukocyte Glucocorticoid Receptor: Preliminary Findings in Healthy Adults
TLDR
Findings suggest that childhood maltreatment or adversity may lead to epigenetic modifications of the human GR gene, which could underlie the associations between childhood adversity, alterations in stress reactivity, and risk for psychopathology. Expand
Childhood Maltreatment and Telomere Shortening: Preliminary Support for an Effect of Early Stress on Cellular Aging
TLDR
The results extend previous reports linking shortened leukocyte telomere length and caregiver stress to more remote stressful experiences in childhood and suggest that childhood maltreatment could influence cellular aging. Expand
Effect of Childhood Emotional Abuse and Age on Cortisol Responsivity in Adulthood
TLDR
Dampened cortisol reactivity might be a consequence of childhood EA that is cumulative over time and Prospective longitudinal investigation is needed to evaluate the potential of this proposed endophenotypes relevant to mood disorders. Expand
Interaction of Childhood Maltreatment with the Corticotropin-Releasing Hormone Receptor Gene: Effects on Hypothalamic-Pituitary-Adrenal Axis Reactivity
TLDR
Variation in the CRHR1 moderates the effect of childhood maltreatment on cortisol responses to the DEX/CRH test, which could represent a mechanism of interactions of risk genes with stress in the development of mood and anxiety disorders. Expand
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