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The Ecoresponsive Genome of Daphnia pulex
The Daphnia genome reveals a multitude of genes and shows adaptation through gene family expansions. We describe the draft genome of the microcrustacean Daphnia pulex, which is only 200 megabases andExpand
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Origin and evolution of spliceosomal introns
Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing, intensive debate. The introns-early concept, later rebranded ‘introns first’ held that protein-coding genesExpand
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Genome-wide Analysis of Substrate Specificities of the Escherichia coli Haloacid Dehalogenase-like Phosphatase Family*
Haloacid dehalogenase (HAD)-like hydrolases are a vast superfamily of largely uncharacterized enzymes, with a few members shown to possess phosphatase, β-phosphoglucomutase, phosphonatase, andExpand
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Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
Methylating the Family Tree DNA sequences show a high level of similarities between humans and ancient hominids but the degree to which there are differences between methylated regions in theirExpand
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Robust linear dimensionality reduction
  • Y. Koren, L. Carmel
  • Computer Science, Medicine
  • IEEE Transactions on Visualization and Computer…
  • 1 July 2004
We present a novel family of data-driven linear transformations, aimed at finding low-dimensional embeddings of multivariate data, in a way that optimally preserves the structure of the data. Expand
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The Function of Introns
The intron–exon architecture of many eukaryotic genes raises the intriguing question of whether this unique organization serves any function, or is it simply a result of the spread of functionlessExpand
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Archaic Adaptive Introgression in TBX15/WARS2
A recent study conducted the first genome-wide scan for selection in Inuit from Greenland using single nucleotide polymorphism chip data. Here, we report that selection in the region with the secondExpand
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ACE: a fast multiscale eigenvectors computation for drawing huge graphs
We present an extremely fast graph drawing algorithm for very large graphs, which exhibits an improvement of something like two orders of magnitude over the fastest algorithms we are aware of; it draws graphs of millions of nodes in less than a minute. Expand
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Endothelial cells promote migration and proliferation of enteric neural crest cells via beta1 integrin signaling.
Enteric neural crest-derived cells (ENCCs) migrate along the intestine to form a highly organized network of ganglia that comprises the enteric nervous system (ENS). The signals driving the migrationExpand
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ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1
Despite the clear major contribution of hyperlipidemia to the prevalence of cardiovascular disease in the developed world, the direct effects of lipoproteins on endothelial cells have remainedExpand
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