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Nicotinic acid: the broad‐spectrum lipid drug. A 50th anniversary review
  • L. Carlson
  • Medicine
  • Journal of internal medicine
  • 1 August 2005
TLDR
A basic effect of nicotinic acid is the inhibition of fat‐mobilizing lipolysis in adipose tissue leading to a lowering of plasma free fatty acids, which has many metabolic implications which are reviewed. Expand
Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid.
TLDR
The fact that the decrease in IHD deaths was directly related to the degree of serum triglyceride lowering indicates that it was the drug effect on serum lipids that was responsible for the beneficial effect of the treatment. Expand
ACUTE EFFECTS OF PROLONGED, HEAVY EXERCISE ON THE CONCENTRATION OF PLASMA LIPIDS AND LIPOPROTEINS IN MAN.
TLDR
Mechanism(s) for changes in the concentration of the plasma lipids and lipoproteins during prolonged, heavy exercise were discussed. Expand
Changes in plasma very low density and low density lipoprotein content, composition, and size after a fatty meal in normo- and hypertriglyceridemic man.
TLDR
Four subfractions of plasma VLDL characterized by decreasing Sf value and LDL were isolated by density gradient preparative ultracentrifugation from normotriglyceridemic and hypertriglyceridemia subjects in the fasting state and after a fatty meal to show that the hyperlipidemia of type IV subjects was accounted for by an increase in total numbers of VLDl and a shift in the distribution of V LDL towards particles of larger diameter. Expand
Metabolism of triglyceride-rich lipoproteins during alimentary lipemia.
TLDR
It is indicated that chylomicrons compete with VLDL for removal of triglycerides by lipoprotein lipase and that the postprandial metabolism of triglyceride-rich lipoproteins is severely defective in hypertriglyceridemia. Expand
Risk factors for myocardial infarction in the Stockholm prospective study. A 14-year follow-up focussing on the role of plasma triglycerides and cholesterol.
TLDR
A 14-year follow-up of the Stockholm prospective study on myocardial infarctions shows that age, blood pressure, smoking, fasting plasma concentrations of cholesterol and triglycerides, ESR and Hb were independent risk factors for MI, while the weight/height index was not. Expand
Classification of hyperlipidaemias and hyperlipoproteinaemias.
TLDR
The present memorandum presents a classification of the main types of hyperlipidaemia, based on lipoprotein analyses by electrophoresis and ultracentrifugation, and briefly describes the criteria for diagnosis as well as the methods of their determination. Expand
Fish eye disease: a new familial condition with massive corneal opacities and dyslipoproteinaemia Clinical and laboratory studies in two afflicted families
TLDR
The disease is described in two unrelated families and in both there was a high proportion of low HDL in relatives without eye disease. Expand
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