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The A1 adenosine receptor as a new player in microglia physiology
It is found that microglial cells express A1AR and that it is highly upregulated upon ATP treatment, and it is observed that selective stimulation of A1 AR inhibits the morphological activation of microglia, possibly by suppressing the Ca2+ influx induced by ATP treatment. Expand
The essential oil from industrial hemp (Cannabis sativa L.) by-products as an effective tool for insect pest management in organic crops
Light is shed on the possible utilization of the crop residue of industrial hemp as a source of environmental-friendly botanical insecticides to be used in Integrated Pest Management and organic agriculture, particularly to manage aphid and housefly populations. Expand
Acute and sub-lethal toxicity of eight essential oils of commercial interest against the filariasis mosquito Culex quinquefasciatus and the housefly Musca domestica
Commercial valuable essential oils selected showed a highly promising insecticidal potential on two key insect vectors and pests as well as to a reduction in fecundity, fertility, and natality in acute and sub-lethal toxicity assays. Expand
Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.
Conformational analysis based on vicinal protonminus signproton J-coupling constants and molecular mechanics calculations using the MM2 force field proved that the methyl group on C1' in adenosine has a pronounced impact on the furanose conformation by driving its conformational equilibrium toward the north, gamma+, syn form. Expand
Origanum syriacum subsp. syriacum: From an ingredient of Lebanese ‘manoushe’ to a source of effective and eco-friendly botanical insecticides
Taken together, these results promote carvacrol-rich Za’tar EO as a promising reservoir of green insecticides to be used for managing insect pests and vectors of economic relevance. Expand
Diverse biological effects of the essential oil from Iranian Trachyspermum ammi
Abstract Trachyspermum ammi (Apiaceae) is a plant with a good reputation in the traditional Persian and Ayurvedic medicine. The hydrodistilled essential oil from the fruits of T. ammi , known asExpand
2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
2-chloro-2'-C-methyl-N6-cyclopentyladenosine (2'-Me-CCPA), which displayed a Ki value of 1.8 nM at A1 receptors, was selective for A1 vs A2A and A3 receptors by 2166- and 2777-fold, respectively, resulting in one of the most potent and A1-selective agonists so far known. Expand
Not just popular spices! Essential oils from Cuminum cyminum and Pimpinella anisum are toxic to insect pests and vectors without affecting non-target invertebrates
Two popular spices of economic importance, cumin and anise, showed noteworthy effects against all pest targets and were definitely devoid of toxic effects on E. fetida and H. axyridis when compared at sub-lethal concentrations with the commercial insecticide α-cypermethrin. Expand
Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis.
The authors' finding that TrMP is only a substrate with NMNAT1 and NMNAT3 reveals for the first time an organelle selectivity in the metabolism of this important drug, allowing us to quantify individual isozyme contributions to NAD+ formation in human cell extracts. Expand