L. Caparrotta

Publications131
h-index21
Citations1,457
Highly Influential Citations34
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Oestrogens ameliorate mitochondrial dysfunction in Leber's hereditary optic neuropathy.
TLDR
A metabolic basis for the unexplained male prevalence in Leber's hereditary optic neuropathy is supported and promises for a therapeutic use for oestrogen-like molecules are held and it is shown that the oestrogens receptor β localizes to the mitochondrial network of human retinal ganglion cells.
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"Metabolic reprogramming" in ovarian cancer cells resistant to cisplatin.
TLDR
A "metabolic remodelling" of ovarian carcinoma cells to a lipogenic phenotype, which includes alteration of mitochondrial function, as an advantageous mechanism to escape cisplatin-induced apoptosis is proposed.
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Dual effect of ATP and UTP on rat atria: which types of receptors are involved?
TLDR
It is demonstrated that ATP may induce negative inotropism directly by an action on A1-adenosine receptors and positive inotropic effect mediated by Suramin-sensitive receptors by action on P2x-purinoceptors.
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Aescin protection of human vascular endothelial cells exposed to cobalt chloride mimicked hypoxia and inflammatory stimuli.
TLDR
Pre-treatment of HUVECs with aescin prevented, in a concentration-dependent fashion, the action of CoCl2 on VCAM-1 and PECam-1, also preserving endothelial cell morphology, and reduced IL-6 release from LPS-activated vascular endothelium.
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Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death
TLDR
This work characterized the role of metabolic transformation in cisplatin resistance and found that C13 cells not only present an increased glucose-uptake and consumption, but also exhibit increased expression and enzymatic activity of the Pentose Phosphate pathway (PPP) enzyme Glucose-6-Phosphate Dehydrogenase (G6PDH).
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Cell‐cycle inhibition and apoptosis induced by curcumin and cisplatin or oxaliplatin in human ovarian carcinoma cells
TLDR
Epidemiological and experimental studies suggest that curcumin protects against cancer, not only because of its well‐known antioxidant properties, but also because it modulates intracellular signalling, which is related to cell proliferation and apoptosis.
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Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines.
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Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage
TLDR
Positive correlation of the antioxidant activity with the mechanism involved in the physiologic maintenance of the integrity and function of the intestinal epithelium is shown, supporting its use as safe adjuvant in patients affected by IBD.
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P2X-purinoceptors in the heart: actions of ATP and UTP.
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Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell Lines
TLDR
The results suggest that quercetin, exceeding the resistance to CDDP, might become an interesting tool to evaluate cytotoxic activity in combination with chemotherapy drugs.
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