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LKB1/STRAD Promotes Axon Initiation During Neuronal Polarization
Axon/dendrite differentiation is a critical step in neuronal development. In cultured hippocampal neurons, the accumulation of LKB1 and STRAD, two interacting proteins critical for establishingExpand
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Excitatory GABA Action Is Essential for Morphological Maturation of Cortical Neurons In Vivo
GABA exerts excitatory actions on embryonic and neonatal cortical neurons, but the in vivo function of this GABA excitation is essentially unknown. Using in utero electroporation, we eliminated theExpand
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Modulation of GABAergic Transmission by Activity via Postsynaptic Ca2+-Dependent Regulation of KCC2 Function
Activity-induced modification of GABAergic transmission contributes to the plasticity of neural circuits. In the present work we found that prolonged postsynaptic spiking of hippocampal neurons ledExpand
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Local and Long-Range Reciprocal Regulation of cAMP and cGMP in Axon/Dendrite Formation
Promoting Axon Formation How do neurons initiate one axon and lots of dendrites? Using an in vitro assay involving stripes of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphateExpand
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Developmental Downregulation of Histone Posttranslational Modifications Regulates Visual Cortical Plasticity
The action of visual experience on visual cortical circuits is maximal during a critical period of postnatal development. The long-term effects of this experience are likely mediated by signalingExpand
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Acceleration of Visual System Development by Environmental Enrichment
Thus far, the developmental plasticity of the visual system has been studied by altering or reducing visual experience. Here, we investigated whether a complex sensory-motor stimulation, provided byExpand
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Reducing Intracortical Inhibition in the Adult Visual Cortex Promotes Ocular Dominance Plasticity
Experience-dependent plasticity in the cortex is often higher during short critical periods in postnatal development. The mechanisms limiting adult cortical plasticity are still unclear. MaturationExpand
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Enriched environment and acceleration of visual system development
Rearing mice from birth in an enriched environment leads to a conspicuous acceleration of visual system development appreciable at behavioral, electrophysiological and molecular level. Little isExpand
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Semaphorin3A Regulates Neuronal Polarization by Suppressing Axon Formation and Promoting Dendrite Growth
Semaphorin 3A (Sema3A) is a secreted factor known to guide axon/dendrite growth and neuronal migration. We found that it also acts as a polarizing factor for axon/dendrite development in culturedExpand
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Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome
Down syndrome (DS) is the most frequent genetic cause of intellectual disability, and altered GABAergic transmission through Cl−-permeable GABAA receptors (GABAARs) contributes considerably toExpand
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