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Excitatory GABA Action Is Essential for Morphological Maturation of Cortical Neurons In Vivo
GABA exerts excitatory actions on embryonic and neonatal cortical neurons, but the in vivo function of this GABA excitation is essentially unknown. Using in utero electroporation, we eliminated the
Local and Long-Range Reciprocal Regulation of cAMP and cGMP in Axon/Dendrite Formation
It is found that localized cAMP and cGMP activities in undifferentiated neurites of cultured hippocampal neurons promote and suppress axon formation, respectively, and exert opposite effects on dendrite formation.
Acceleration of Visual System Development by Environmental Enrichment
Rearing mice from birth in an enriched environment causes an earlier eye opening, a precocious development of visual acuity, and an accelerated decline of white matter-induced long-term potentiation as ascertained at behavioral, electrophysiological, and molecular level.
Reducing Intracortical Inhibition in the Adult Visual Cortex Promotes Ocular Dominance Plasticity
It is found that reduction of GABAergic transmission in the adult rat visual cortex partially reactivates OD plasticity in response to monocular deprivation (MD) and a decrease in the expression of chondroitin sulfate proteoglycans in the visual cortex of MD animals with reduced inhibition is found.
Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome
It is demonstrated that GABA is excitatory in adult DS mice and a new therapeutic approach is identified for the potential rescue of cognitive disabilities in individuals with DS.