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CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation
CX3CR1 expression is associated with the commitment of CSF-1R+ myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R+ CX3CR1+ macrophage/DCExpand
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Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T‐cell responses
Monocytes can have important effects on the polarization and expansion of lymphocytes and may contribute to shaping primary and memory T‐cell responses in humans and mice. However, their preciseExpand
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A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells.
Dendritic cells (DCs) have the striking ability to cross-present exogenous antigens in association with major histocompatibility complex (MHC) class I to CD8(+) T cells. However, the intracellularExpand
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Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation
Unwinding DNA and unleasing inflammation Fighting infections often comes with collateral damage, which sometimes can be deadly. For instance, in septic shock, the overwhelming release of inflammatoryExpand
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The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity
The nuclear RNA exosome is an essential multi-subunit complex that controls RNA homeostasis. Congenital mutations in RNA exosome genes are associated with neurodegenerative diseases. Little is knownExpand
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Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.
Viruses are obligate parasites and thus require the machinery of the host cell to replicate. Inhibition of host factors co-opted during active infection is a strategy hosts use to suppress viralExpand
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Phytoene Accumulation in Sunflower Decreases the Transcript Levels of the Phytoene Synthase Gene
The non dormant-1 (nd-1) mutant of sunflower (Helianthus annuus L.) and fluridone-treated plants were used to investigate the effect of phytoene accumulation on the transcript levels of the phytoeneExpand
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HIV-1 Infection of Primary CD4+ T Cells Regulates the Expression of Specific Human Endogenous Retrovirus HERV-K (HML-2) Elements
ABSTRACT Endogenous retroviruses (ERVs) occupy extensive regions of the human genome. Although many of these retroviral elements have lost their ability to replicate, those whose insertion took placeExpand
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Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection
Summary RNA viruses are a major human health threat. The life cycles of many highly pathogenic RNA viruses like influenza A virus (IAV) and Lassa virus depends on host mRNA, because viral polymerasesExpand
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Apoptosis in response to microbial infection induces autoreactive TH17 cells
Microbial infections often precede the onset of autoimmunity. How infections trigger autoimmunity remains poorly understood. We investigated the possibility that infection might create conditionsExpand
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