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Chromosomes Can Congress to the Metaphase Plate Before Biorientation
TLDR
In mammalian cells, it is found that chromosomes can congress before becoming bioriented, and this congression mechanism depended on the kinetochore-associated, plus end–directed microtubule motor CENP-E (kinesin-7). Expand
Motility of ActA protein-coated microspheres driven by actin polymerization.
TLDR
The actin polymerization-based motility generated by ActA can be used to move nonbiological cargo, as has been demonstrated for classical motor molecules such as kinesin and myosin. Expand
Determining the position of the cell division plane
TLDR
By inducing mammalian tissue cells with monopolar spindles to enter anaphase, it is shown that furrow formation in cultured mammalian cells does not require a bipolar spindle and is consistent with a model in which chromosomes supply microtubules with factors that promote microtubule stability and furrowing. Expand
Anaphase Spindle Mechanics Prevent Mis-Segregation of Merotelically Oriented Chromosomes
TLDR
A model based on the ratios of microtubules to the correct versus incorrect pole for how anaphase spindle dynamics and microtubule polymerization at kinetochores prevent potential segregation errors deriving from merotelic Kinetochore orientation is proposed. Expand
XRHAMM Functions in Ran-Dependent Microtubule Nucleation and Pole Formation during Anastral Spindle Assembly
TLDR
The Xenopus ortholog of human RHAMM is identified as a microtubule-associated protein that plays a role in focusing spindle poles and is essential for efficient micro Tubule nucleation during spindle assembly without centrosomes. Expand
Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle
TLDR
It is found that the flux velocity decreases near spindle poles by ∼20%. Expand
The coupling between sister kinetochore directional instability and oscillations in centromere stretch in metaphase PtK1 cells
High-resolution kinetochore tracking reveals that oscillations in centromere stretch occur at twice the frequency of kinetochore oscillations because of the nonlinear kinetics of kinetochoreExpand
Dendritic organization of actin comet tails
TLDR
It is shown that actin filament arrays in comet tails in fact have a dendritic organization with the Arp2/3 complex localizing to Y-junctions as in lamellipodia, and these two systems appear to share a common dendedritic nucleation mechanism for protrusive motility. Expand
Proinvasion metastasis drivers in early-stage melanoma are oncogenes.
TLDR
This integrated effort identified six genes that are potently proinvasive and oncogenic and it is shown that one such gene, ACP5, confers spontaneous metastasis in vivo, engages a key pathway governing metastasis, and is prognostic in human primary melanomas. Expand
Kinesin 5–independent poleward flux of kinetochore microtubules in PtK1 cells
TLDR
The data reveal that the majority of poleward flux of kMTs in these cells is not driven by tetrameric kinesin Eg5, and favor a polar “pulling-in” mechanism in which a depolymerase localized at kinetochore fiber minus ends makes a major contribution to Poleward flux. Expand
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