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Early Pharmacotherapy Restores Neurogenesis and Cognitive Performance in the Ts65Dn Mouse Model for Down Syndrome
TLDR
Results show that early pharmacotherapy with a drug usable by humans can correct neurogenesis and behavioral impairment in a model for DS, and that proliferation was completely rescued by fluoxetine. Expand
Endocrine Disrupters: A Review of Some Sources, Effects, and Mechanisms of Actions on Behaviour and Neuroendocrine Systems
TLDR
EDCs, from varied sources, may have organisational effects during development and/or activational effects in adulthood that influence sexually‐dimorphic, reproductively‐relevant processes or other functions, by mimicking, antagonising or altering steroidal actions. Expand
Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors
TLDR
The present investigation suggests that the increase of scg size induced by NGF and 6-OHDA + NGF is associated with neoangiogenesis, and that the induction of vasoactive and angiogenic factors in neurons represents a further and previously undisclosed effect of NGF. Expand
Proliferation and phenotype regulation in the subventricular zone during experimental allergic encephalomyelitis: in vivo evidence of a role for nerve growth factor.
TLDR
An increase in the proliferation activity in the SVZ during experimental allergic encephalomyelitis, a demyelinating disease widely used as an experimental model for human multiple sclerosis, indicates that cell populations inThe SVZ are regulated during inflammatory conditions and degenerative diseases involving oligodendrocytes and neurotrophins, including nerve growth factor, could participate in these phenomena. Expand
Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis
TLDR
The possibility of promoting myelination in experimental allergic encephalomyelitis by recruiting progenitors and channeling them into oligodendroglial lineage through administration of thyroid hormone (T4) is explored. Expand
Long-Lasting Regulation of Galanin, Opioid, and Other Peptides in Dorsal Root Ganglia and Spinal Cord during Experimental Polyarthritis
TLDR
The results suggest that in the remission stage of chronic joint inflammation several types of mechanisms are activated aiming at counteracting both inflammatory and neuropathic pain. Expand
NOS mRNA in the paraventricular nucleus of young and old rats after immobilization stress.
TLDR
The present results suggest that nitric oxide in the PVN may be involved in the stress response and the differences observed in NOS mRNA between young and old rats could be related to an age-dependent different responsiveness to stressful stimuli. Expand
Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats.
TLDR
It is demonstrated that a selective deficit in learning and memory performance, as investigated by the Morris water maze test, is a consistent feature in rat encephalomyelitis, which correlates with a decline in choline acetyltransferase activity and nerve growth factor mRNA level in cerebral cortex, hippocampus, and basal forebrain. Expand
Neural stem cells and cholinergic neurons: Regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor
TLDR
The results suggest that pharmacological control of endogenous neural stem cells can provide an additional opportunity for brain repair, and offer useful information for improving integration of transplanted cells into the mature brain. Expand
Pharmacotherapy with Fluoxetine Restores Functional Connectivity from the Dentate Gyrus to Field CA3 in the Ts65Dn Mouse Model of Down Syndrome
TLDR
The positive effects of fluoxetine on the DG-CA3 system suggest that early treatment with this drug could be a suitable therapy, possibly usable in humans, to restore the physiology of the hippocampal networks and, hence, memory functions. Expand
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