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The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
TLDR
Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 h post infection able to effect ~5000-fold reduction in viral RNA at 48 h. Expand
Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
TLDR
The kinetics of immune responses in relation to clinical and virological features of a patient with mild-to-moderate coronavirus disease 2019 (COVID-19) that required hospitalization were reported and immunological changes persisted for at least 7 d following full resolution of symptoms. Expand
SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
TLDR
The sensitivity of the two viruses to three established inhibitors of coronavirus replication is very similar, but that SARS-CoV-2 infection was substantially more sensitive to pre-treatment of cells with pegylated interferon alpha. Expand
Isolation and rapid sharing of the 2019 novel coronavirus (SARS‐CoV‐2) from the first patient diagnosed with COVID‐19 in Australia
TLDR
The first isolation and sequencing of SARS‐CoV‐2 in Australia and rapid sharing of the isolate are described and the isolate is described for the first time. Expand
Direct RNA sequencing and early evolution of SARS-CoV-2
TLDR
The first native RNA sequence of SARS-CoV-2 is described, detailing the coronaviral transcriptome and epitranscriptome, and a data-driven inference of viral genetic features and evolutionary rate is made. Expand
Tracking the COVID-19 pandemic in Australia using genomics
TLDR
The application of genomics to rapidly identify SARS-CoV-2 transmission chains will become critically important as social restrictions ease globally and public health responses to emergent cases must be swift, highly focused and effective. Expand
SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
TLDR
The sensitivity of the two viruses to three established inhibitors of coronavirus replication is very similar, but that SARS-CoV-2 infection was substantially more sensitive to pre-treatment of cells with pegylated interferon alpha. Expand
SARS-CoV-2 Variants of Interest and Concern naming scheme conducive for global discourse.
TLDR
This exhibition celebrates the 50th anniversary of the publication of the first book of this kind to be published in the United States, edited by David I. Dickinson and Maria D. van Kerkhove. Expand
New Host Factors Important for Respiratory Syncytial Virus (RSV) Replication Revealed by a Novel Microfluidics Screen for Interactors of Matrix (M) Protein*
TLDR
Novel interactors identified included proteins involved in host transcription regulation, the innate immunity response, cytoskeletal regulation, membrane remodeling, and cellular trafficking, which have important implications for future antiviral strategies aimed at targets of RSV matrix in the host cell. Expand
Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV?
TLDR
A review of the complex and controversial literature regarding three PIC components--the HIV proteins matrix, integrase and Vpr--proposed to facilitate PIC nuclear import, and existing models of HIV PICnuclear import suggests approaches to move towards a better understanding of Pic nuclear import. Expand
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