• Publications
  • Influence
Studies on the stability and detection of cocaine, benzoylecgonine, and 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid in whole blood using Abuscreen radioimmunoassay.
TLDR
Despite cocaine's instability in blood, RIA was able to detect the presence of cocaine and its breakdown products in blood under all conditions studied. Expand
Evaluation of the Ion Trap Detector for the detection of 11-nor-delta 9-THC-9-carboxylic acid in urine after extraction by bonded-phase adsorption.
TLDR
The ITD was evaluated for its suitability in confirming urine specimens found positive for cannabinoids by immunoassay techniques and a procedure for the isolation of 11-nor-delta 9-THC-9-carboxylic acid from human urine by bonded-phase absorption chromatography was presented. Expand
Molecular structure of deoxycytidyl-3'-methylphosphonate (RP) 5'-deoxyguanidine, d[Cp(CH3)G]. A neutral dinucleotide with Watson-Crick base pairing and a right handed helical twist.
TLDR
The crystal structure of d[Cp(CH3)G] has been determined and a mechanism, based on this assignment, is presented for the B----Z transition in DNA. Expand
Synthesis and properties of a nonhydrolyzable adenosine phosphosulfate analog.
TLDR
This paper describes the simple and efficient synthesis and structural confirmation of a nonhydrolyzable APS analog, beta-methylene APS, with an overall molar yield of 40-50%. Expand
B- to Z-DNA transition probed by oligonucleotides containing methylphosphonates.
TLDR
The studies suggest that the B--Z-DNA transition is regulated both thermodynamically and kinetically through hydrogen-bond interactions involving phosphate oxygens and the N-2 amino group of guanine. Expand
Comparative sensitivity of different methods to detect and quantify circulating fibrinogen/fibrin split products.
TLDR
All three methods are comparable in their abilities to detect abnormal levels of fibrinogen/fibrin split products (FSP) in blood samples from 696 patients and 124 normal donors. Expand
Dibasic amines as competitive ions improve the resolution between polyanionic nucleotides.
TLDR
The ability to easily resolve these positional isomers allows the use of a more simplified synthetic procedure that does not involve the use selective protecting groups to specifically phosphorylate the 2' or 3' hydroxyl group. Expand
Synthesis and utilization of a nonhydrolyzable phosphoadenosine phosphosulfate analog.
TLDR
The synthesis of the 2'- and 3'-isomers of a nonhydrolysable, and thus stable, PAPS analog, beta-methylene-PAPS, from the previously described beta- methylene-APS is described. Expand
Comparative sensitivity of different methods to detect and quantify circulating fibrinogen/fibrin split products.
TLDR
All three methods are comparable in their abilities to detect abnormal levels of fibrinogen/fibrin split products (FSP) in blood samples from 696 patients and 124 normal donors. Expand
Optimization of Radiopharmacy by Redesign
TLDR
Redesign has improved the quality of radiopharmaceutical dispensing, cell labeling, and quality control and was accomplished utilizing the existing floor space and at a relatively reasonable cost. Expand