L. Cai

Publications135
h-index20
Citations975
Highly Influential Citations50
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Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2
Cancer cells recruit monocytes, macrophages and other inflammatory cells by producing abundant chemoattractants and growth factors, such as macrophage colony-stimulating factor (M-CSF/CSF-1) and… Expand
  • 83
  • 6
Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a case–control study in China
Background/Aims: The risk factors for cholangiocarcinoma are incompletely defined in China, especially for intrahepatic cholangiocarcinoma (ICC). We evaluated the risk factors for both ICC and… Expand
  • 76
  • 5
Study on TP53 codon 72 polymorphisms with oral carcinoma susceptibility.
BACKGROUND AND AIMS Previous published data have implicated TP53 codon 72 polymorphisms as risk factors for various cancers. Growing bodies of studies have been conducted on the association of TP53… Expand
  • 22
  • 4
Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1
The tumor microenvironment is emerging as an important target for cancer therapy. Fibroblasts (Fbs) within the tumor stroma are critically involved in promoting tumor growth and angiogenesis through… Expand
  • 49
  • 3
TP53 codon 72 polymorphism contributes to nasopharyngeal cancer susceptibility: a meta-analysis.
BACKGROUND AND AIMS Previously, TP53 codon 72 polymorphisms have been implicated as risk factors for various cancers. Several studies have been conducted on the association of TP53 codon 72… Expand
  • 29
  • 3
NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP
Parkinson's disease (PD) is characterized by progressing loss of dopaminergic neurons in the midbrain. Abnormal gene expression plays a critical role in its pathogenesis. Neuron-restrictive silencer… Expand
  • 35
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NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease
Neuron-restrictive silencer factor (NRSF) blocks the expression of many neuronal genes in non-neuronal cells and neural stem cells. There is growing body of evidence that NRSF functions in mature… Expand
  • 23
  • 2
Aberrant expression of GATA binding protein 6 correlates with poor prognosis and promotes metastasis in cholangiocarcinoma.
AIM GATA6, a zinc-finger transcription factor, functions as a tumour promoter or suppresser according to different tumour origins. We investigated the clinical significance of GATA6 and its role in… Expand
  • 27
  • 2
Clinicopathological features and prognosis of gastric cancer in young patients
BackgroundThe clinicopathological features and prognosis of gastric cancer in young patients are both limited and controversial. Therefore, the aim of this study was to define the clinicopathological… Expand
  • 32
  • 2
Polymorphisms of TP53 codon 72 with breast carcinoma risk: evidence from 12226 cases and 10782 controls
BackgroundPreviously, TP53 codon 72 polymorphisms have been implicated as risk factors for various cancers. A number of studies have conducted on the association of TP53 codon 72 polymorphisms with… Expand
  • 35
  • 2