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Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer's disease pathology
Alzheimer's disease (AD) is a neurodegenerative disorder in which chronic neuroinflammation contributes to disease escalation. Nevertheless, while immunosuppressive drugs have repeatedly failed inExpand
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CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging
The adaptive arm of the immune system has been suggested as an important factor in brain function. However, given the fact that interactions of neurons or glial cells with T lymphocytes rarely occurExpand
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Dopamine interacts directly with its D3 and D2 receptors on normal human T cells, and activates β1 integrin function
Dopamine by itself has not up to now been reported to activate T cell function. We show here that dopamine interacts directly with dopaminergic receptors on normal human T cells and triggers β1Expand
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Extracellular K+ and Opening of Voltage-Gated Potassium Channels Activate T Cell Integrin Function
Elevated extracellular K+ ([K+]o), in the absence of “classical” immunological stimulatory signals, was found to itself be a sufficient stimulus to activate T cell β1 integrin moieties, and to induceExpand
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IL-2 induces T cell adherence to extracellular matrix: inhibition of adherence and migration by IL-2 peptides generated by leukocyte elastase.
Migration of inflammatory cells requires cell adhesion and their subsequent detachment from the extracellular matrix (ECM). Leukocyte activation and migration must be terminated to stop inflammation.Expand
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The Cell-binding Domain of Intimin from Enteropathogenic Escherichia coli Binds to β1 Integrins*
Bacteria interact with mammalian cells surface molecules, such as integrins, to colonize tissues and evade immunological detection. Herein, the ability of intimin, an outer membrane protein fromExpand
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Low-dose low-molecular-weight heparin (enoxaparin) is beneficial in lichen planus: a preliminary report.
BACKGROUND Low-dose heparin devoid of anticoagulant activity inhibits T-lymphocyte heparanase activity, which is crucial in T-cell migration to target tissues. OBJECTIVE The purpose of this studyExpand
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Heterologous desensitization of T cell functions by CCR5 and CXCR4 ligands: inhibition of cellular signaling, adhesion and chemotaxis.
T cells migrate into inflamed sites through the extracellular matrix (ECM) in response to chemotactic areas and are then simultaneously or sequentially exposed to multiple chemotactic ligands. WeExpand
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Neuropeptides, via specific receptors, regulate T cell adhesion to fibronectin.
The ability of T cells to adhere to and interact with components of the blood vessel walls and the extracellular matrix is essential for their extravasation and migration into inflamed sites. We haveExpand
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