L. C. Nascimento da Silva

Publications27
h-index11
Citations297
Highly Influential Citations13
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Polysaccharide-Based Formulations for Healing of Skin-Related Wound Infections: Lessons from Animal Models and Clinical Trials
TLDR
The papers show that these polysaccharides-based formulations are efficient in controlling infection and improve the healing, even in chronic infected wounds, which should positively impact the design of new dressings to treat skin infections.
Organic extracts from Indigofera suffruticosa leaves have antimicrobial and synergic actions with erythromycin against Staphylococcus aureus
TLDR
Organic extracts from leaves of I. suffruticosa, alone or combined with erythromycin, are promising natural products for the development of new anti-S.
Lectin-Carbohydrate Interactions: Implications for the Development of New Anticancer Agents.
TLDR
In both cases (lectin-conjugated polymers or encapsulated lectins), these new pharmaceutical preparations showed improved intracellular delivery, bioavailability and targetability leading to enhanced therapeutic index and significantly less side effects.
Exploring lectin-glycan interactions to combat COVID-19: lessons acquired from other enveloped viruses
TLDR
The data compiled in this review highlights the importance of structural studies aiming to improve knowledge about the basis of glycan recognition by lectins and its repercussions in several fields, providing potential solutions for complex aspects that are emerging from different health challenges.
Antimicrobial Activity and Phytochemical Analysis of Organic Extracts from Cleome spinosa Jaqc.
TLDR
All C. spinosa extracts showed a broad spectrum of antimicrobial activity, as they have inhibited all tested bacteria and yeasts, and the identification of active substances which could be used as lead(s) molecules in the development of new antimicrobial drugs is encouraged.
Anti-staphylococcal activity of Syagrus coronata essential oil: Biofilm eradication and in vivo action on Galleria mellonela infection model.
Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions
TLDR
B Buchenavia tetraphylla methanolic extract (BTME) is a great source of antimicrobial compounds that are able to enhance the action of fluconazole against different C. albicans strains; this action seems related to inhibition of cell division.
Antimicrobial Activity and Phytochemical Screening of Buchenavia tetraphylla (Aubl.) R. A. Howard (Combretaceae: Combretoideae)
TLDR
This work showed for the first time the broad-spread antimicrobial activity of B. tetraphylla, which has nonhemolytic action, creating a new perspective on the interesting association of traditional and scientific knowledge.
Schinus terebinthifolia leaf lectin (SteLL) has anti-infective action and modulates the response of Staphylococcus aureus-infected macrophages
TLDR
Evidence suggest SteLL as important lead molecule in the development of anti-infective agents against S. aureus as well as in vitro assays and an infection model based on Galleria mellonella larvae suggest that SteLL impairs cell division.
Evaluation of Antioxidant, Immunomodulatory, and Cytotoxic Action of Fractions from Eugenia uniflora L. and Eugenia malaccensis L.: Correlation with Polyphenol and Flavanoid Content
TLDR
It was observed that the polyphenol content was higher in ethyl acetate fractions, which have high antioxidant potential, and species of the family Myrtaceae are rich in compounds with antioxidant capacity, which can help reduce the inflammatory response.
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