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The fate of pentobarbital in man and dog and a method for its estimation in biological material.
A method is described for the estimation of pentobarbital and other oxy-barbiturates in biological fluids and tissues. Pentobarbital is almost entirely metabolized in man. A major metabolic productExpand
  • 193
  • 2
The fate of thiopental in man and a method for its estimation in biological material.
  • 72
  • 2
The physiological disposition and cardiac effects of procaine amide.
Procaine amide, the amide analogue of procaine, is relatively stable in the body since it is not affected by the enzyme which catalyzes the rapid hydrolysis of procaine. It is rapidly and completelyExpand
  • 159
  • 1
Metabolism of barbiturates in man
Barbiturate effeets in man are limited by various proeesses. These include redistribution of unehanged drug within the body, development of toleranee, renal exeretion, and metabolie transformation.Expand
  • 68
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Metabolism of the barbiturates.
  • L. C. Mark
  • Medicine
  • Annals of the Royal College of Surgeons of…
  • 1 February 1971
  • 12
  • 1
A lone case of gangrene following intraarterial thiopental 2.5%.
  • 2
  • 1
Metabolism of drugs and carcinogens by human liver enzymes.
Human liver contains enzyme systems which catalyze the ring hydroxylation of 3,4-benzpyrene, the side chain oxidation of pentobarbital, the O-dealkylation of acetophenetidin and the N-dealkylation ofExpand
  • 147
The passage of thiobarbiturates and their oxygen analogs into brain.
Thiobarbiturates pass into brain more rapidly than do their oxygen analogs. This is probably due to their higher lipid solubility, rather than to any specific effect of the sulfur-substitution in theExpand
  • 48
Cytochromes P‐450 and bs in human liver microsomes
Cytochromes P‐450 and b, have been demonstrated in human liver microsomes. The carbon monoxide and ethyl isocyanide difference spectra of cytochrome P‐450 in human liver are similar to those observedExpand
  • 61
Acute tolerance to thiopental.
After a large dose of thiopental, human subjects awake at plasma levels that are considerably higher than those occurring after smaller doses. This tolerance is probably a tissue adaptation to theExpand
  • 48