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anti-Benzo[a]pyrene-7,8-diol-9,10-epoxide Treatment Increases Levels of the Proteins p53 and p21WAF1 in the Human Mammary Carcinoma Cell Line MCF-7
Abstract The tumor suppressor p53 is involved in the recognition of DNA damage induced by radiation and chemicals. The effect of polycyclic hydrocarbons on p53 was investigated by treating MCF-7Expand
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Molecular biology of nickel carcinogenesis: Identification of differentially expressed genes in morphologically transformed C3H10T1/2 Cl 8 mouse embryo fibroblast cell lines induced by pecific
Inhalation of mixtures of insoluble and soluble nickel compounds by humans during nickel refining has been associated with excess lung and nasal sinus cancers. Insoluble nickel subsulfide (Ni3S2) andExpand
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Zinc deficiency increases the frequency of single-strand DNA breaks in rat liver
Zinc affects the structural configuration of DNA and chromatin. The objective of this study was to determine whether zinc deficiency alters the frequency of single-strand breaks in rat hepatic DNAExpand
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Relationship of Dibenzo[a, l]pyrene-DNA Binding to the Induction of p53, p21 WAFI and Cell Cycle Arrest in Human Cells in Culture
Abstract The tumor suppressor protein p53 plays an important role in recognition of DNA damage and induction of subsequent cell cycle arrest. One of its target genes encodes the p21 WAFI proteinExpand
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