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The virosome concept for influenza vaccines.
By virtue of these characteristics, virosomes represent a promising novel class of inactivated influenza vaccines, which not only induce high virus-neutralizing antibody titres, but also prime the cellular arm of the immune system. Expand
Microneedle arrays for the transcutaneous immunization of diphtheria and influenza in BALB/c mice.
- Z. Ding, F. Verbaan, +5 authors J. Bouwstra
- Journal of controlled release : official journal…
- 21 May 2009
TCI of DT and CT with microneedle treatment results in comparable protection as injection of DT-alum, and TCI of influenza vaccine adjuvanted with CT is superior to the injection of plain vaccine. Expand
Virosome-mediated delivery of protein antigens to dendritic cells.
Fusion activity of virosome was not required for MHC class II presentation of antigen, and virosomes are an efficient system for delivery of protein antigens for stimulation of both helper and CTL responses. Expand
N-trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model.
It was shown that more than 75% of the protein remained associated with the TMC nanoparticles upon incubation of the particles in PBS for 3h, and the molecular weight and antigenicity of the entrapped hemagglutinin was maintained as shown by polyacrylamide gel electrophoresis and Western blotting. Expand
Delivery of Protein Antigens to the Immune System by Fusion-Active Virosomes: A Comparison with Liposomes and ISCOMs
A number of lipid-based antigen delivery systems suitable for the induction of CTL responses are discussed, focusing on delivery of the protein antigen ovalbumin (OVA) since extensive studies with this antigen have been performed, allowing direct comparison of antigen delivery efficiency. Expand
Induction of cytotoxic T lymphocyte activity by immunization with recombinant Semliki Forest virus: indications for cross-priming.
It is hypothesize that antigen presentation after SFV-based immunization proceeds via a mechanism in which APCs are not transfected directly but acquire antigen from other transfecting cells and present it to CTLs in a process of cross-priming. Expand
Genetic immunization against cervical carcinoma: induction of cytotoxic T lymphocyte activity with a recombinant alphavirus vector expressing human papillomavirus type 16 E6 and E7
Results indicate that E6E7 expression by the efficient and safe recombinant SFV system represents a promising strategy for immunotherapy or immunoprophylaxis of cervical carcinoma. Expand
The formation of autoantibodies and antibodies to TNF-α blocking agents in relation to clinical response in patients with ankylosing spondylitis.
- S. Arends, H. R. Lebbink, +9 authors E. Brouwer
- Clinical and experimental rheumatology
- 1 September 2010
This study indicates that antibody formation to IFX or ADA is related to a decrease in efficacy and early discontinuation of anti-TNF-α treatment in AS patients and autoantibody formation does not seem to be associated with antibodies to TNF- α blocking agents. Expand
Virosome-mediated delivery of protein antigens in vivo: efficient induction of class I MHC-restricted cytotoxic T lymphocyte activity.
- L. Bungener, A. Huckriede, A. de Mare, Jacqueline de Vries-Idema, J. Wilschut, T. Daemen
- Biology, Medicine
- 26 January 2005
Fusion-active virosomes are presented as a vaccine delivery system capable of efficient induction of CTL responses in vivo and represent an ideal antigen delivery system for induction of cellular immunity against encapsulated protein antigens. Expand
Eradication of established HPV16-transformed tumours after immunisation with recombinant Semliki Forest virus expressing a fusion protein of E6 and E7.
- T. Daemen, A. Riezebos‐Brilman, L. Bungener, J. Regts, B. Dontje, J. Wilschut
- Biology, Medicine
- 7 March 2003
It is demonstrated that immunisation of tumour-bearing mice with this improved vector results in the regression and complete elimination of established tumours and that a long-term high level of CTL activity accompanies the anti-tumour response. Expand