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Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.
TLDR
It is shown that missense mutations in ACTA2 are responsible for 14% of inherited ascending thoracic aortic aneurysms and dissections (TAAD), and the importance of SMC contraction in maintaining the structural integrity of the ascending aorta is indicated. Expand
MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II.
TLDR
Data suggest that MYH11 mutations are likely to be specific to the phenotype of TAAD/PDA and result in a distinct aortic and occlusive vascular pathology potentially driven by IGF-1 and Ang II. Expand
Myocardial ischemia and reperfusion injury.
  • L. Buja
  • Medicine
  • Cardiovascular pathology : the official journal…
  • 1 July 2005
TLDR
A detailed understanding is now available of the complexity of the response of the myocardium to an ischemic insult, and ongoing research into the mechanisms involved in reperfusion and preconditioning is yielding new insights into basic myocardial pathobiology. Expand
Mutations in smooth muscle α-actin (ACTA2) lead to thoracic aortic aneurysms and dissections
TLDR
It is shown that missense mutations in ACTA2 are responsible for 14% of inherited ascending thoracic aortic aneurysms and dissections (TAAD), and the importance of SMC contraction in maintaining the structural integrity of the ascending aorta is indicated. Expand
De novo ACTA2 mutation causes a novel syndrome of multisystemic smooth muscle dysfunction
TLDR
A unique and de novo mutation in ACTA2, R179H, is reported here on a syndrome characterized by dysfunction of SMCs throughout the body, leading to aortic and cerebrovascular disease, fixed dilated pupils, hypotonic bladder, malrotation, and hypoperistalsis of the gut and pulmonary hypertension. Expand
The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities
TLDR
The autopsy findings support the concept that the pathogenesis of severe COVID-19 disease involves direct viral-induced injury of multiple organs, including heart and lungs, coupled with the consequences of a procoagulant state with coagulopathy. Expand
Apoptosis and necrosis. Basic types and mechanisms of cell death.
TLDR
These insights point the way for further research to establish definitive causes of specific types of cell injury and cell death, and they provide important clues for the design of improved diagnostic approaches and therapeutic interventions. Expand
Oncosis: an important non-apoptotic mode of cell death.
TLDR
In this review, the many characteristics of oncosis are described from a morphological and biochemical standpoint, and the application ofoncosis in disease processes is briefly examined. Expand
Iron in the heart. Etiology and clinical significance.
TLDR
G grossly visible CID are always associated with cardiac dysfunction and usually chronic cardiac failure, and are usually more extensive in ventricular than in atrial myocardium. Expand
Characterization of the inflammatory and apoptotic cells in the aortas of patients with ascending thoracic aortic aneurysms and dissections.
TLDR
The coexistence of inflammatory cells with markers of apoptotic vascular cell death in the media of ascending aortas with aneurysms and type A dissections raises the possibility that activated T cells and macrophages may contribute to the elimination of smooth muscle cells and degradation of the matrix associated with thoracic aortic aneurYSms and dissections. Expand
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