• Publications
  • Influence
Mitochondrial calcium uptake
Calcium (Ca2+) uptake into the mitochondrial matrix is critically important to cellular function. As a regulator of matrix Ca2+ levels, this flux influences energy production and can initiate cellExpand
Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission
Dynamic assembly and disassembly of F-actin on mitochondria participate in Drp1-mediated mitochondrial fission.
Mitochondrial calcium and the regulation of metabolism in the heart.
Consumption of adenosine triphosphate (ATP) by the heart can change dramatically as the energetic demands increase from a period of rest to strenuous activity. Mitochondrial ATP production is centralExpand
Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein
The data presented support a critical role for MARCH5 in the regulation of mitochondrial fission and cell viability. Through ubiquitin- and proteasome-dependent degradation of MiD49, MARCH5 acts as aExpand
NCLX: the mitochondrial sodium calcium exchanger.
The free Ca(2+) concentration within the mitochondrial matrix ([Ca(2+)]m) regulates the rate of ATP production and other [Ca(2+)]m sensitive processes. It is set by the balance between total Ca(2+)Expand
Kinetic and Equilibrium Properties of Regulatory Calcium Sensors of NCX1 Protein*
The crystal structures of the CBD1 and CBD2 domains of the Na+/Ca2+ exchanger protein (NCX1) provided a major breakthrough in Ca2+-dependent regulation of NCX1, although the dynamic aspects of theExpand
Proton-sensing Ca2+ Binding Domains Regulate the Cardiac Na+/Ca2+ Exchanger*
The cardiac Na+/Ca2+ exchanger (NCX) regulates cellular [Ca2+]i and plays a central role in health and disease, but its molecular regulation is poorly understood. Here we report on how protons affectExpand
A comparative assessment of fluo Ca2+ indicators in rat ventricular myocytes.
The fluo family of indicators is frequently used in studying Ca(2+) physiology; however, choosing which fluo indicator to use is not obvious. Indicator properties are typically determined inExpand
Essential Role of the CBD1-CBD2 Linker in Slow Dissociation of Ca2+ from the Regulatory Two-domain Tandem of NCX1*
In NCX proteins CBD1 and CBD2 domains are connected through a short linker (3 or 4 amino acids) forming a regulatory tandem (CBD12). Only three of the six CBD12 Ca2+-binding sites contribute to NCXExpand
Calcium movement in cardiac mitochondria.
Existing theory suggests that mitochondria act as significant, dynamic buffers of cytosolic calcium ([Ca(2+)]i) in heart. These buffers can remove up to one-third of the Ca(2+) that enters theExpand