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Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use.
This study reinforces the hypothesis that mutations in the DHPS gene are likely involved in the development of sulfa resistance in P. carinii and suggests that there is less selective pressure on DHFR than on DHPS. Expand
Hemorrhagic fever viruses as biological weapons: medical and public health management.
Weapons disseminating a number of HFVs could cause an outbreak of an undifferentiated febrile illness 2 to 21 days later, associated with clinical manifestations that could include rash, hemorrhagic diathesis, and shock. Expand
Death due to bioterrorism-related inhalational anthrax: report of 2 patients.
Clinicians have an urgent need for prompt communication of vital epidemiologic information that could focus their diagnostic evaluation, and rapid diagnostic assays to distinguish more common infectious processes from agents of bioterrorism also could improve management strategies. Expand
Smallpox vaccination in 2003: key information for clinicians.
Hospital preparedness for pandemic influenza.
The FDA animal efficacy rule and biodefense
Overall, Nature Biotechnology remains convinced that the US government needs to do a much better job disseminating information about BioShield and proactively communicating its goals for BARDA and BioShield with companies. Expand
Management of anthrax.
Clinicians are provided with clinically relevant information about the diagnosis and management of anthrax. Expand
Healthcare epidemiology: the current status of planning for pandemic influenza and implications for health care planning in the United States.
The United States needs to be better prepared for a large-scale medical catastrophe, be it a natural disaster, a bioterrorism act, or a pandemic, and some harsh realities are identified. Expand
The use of oral washes to diagnose Pneumocystis carinii pneumonia: a blinded prospective study using a polymerase chain reaction-based detection system.
Oral washes can provide a useful sample for diagnosis of PCP when a sensitive PCR detection system is used, and a dissociation-enhanced lanthanide fluoroimmunoassay time-resolved fluorescent hybridization polymerase chain reaction (PCR) detection system that is feasible for clinical laboratories is used. Expand
Considerations for Developing a Zika Virus Vaccine.
The scientific feasibility of developing a safe, effective Zika vaccine doesn't ensure successful development. An efficient development pathway must be delineated, including better ways to evaluateExpand