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Practical Management of Boceprevir and Immunosuppressive Therapy in Liver Transplant Recipients with Hepatitis C Virus Recurrence

Preliminary results in liver transplant patients with HCV recurrence demonstrate the feasibility and safety of coadministration of boceprevir and IT.
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PRECLINICAL STUDY: Disposition of Δ9 tetrahydrocannabinol in CF1 mice deficient in mdr1a P‐glycoprotein

P‐glycoprotein limits THC oral uptake and mediates direct drug excretion from the systemic circulation into the intestinal lumen, and the oral bioavailability of THC and digoxin was higher in naturally P‐gp‐deficient mice.
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Disposition of everolimus in mdr1a-/1b- mice and after a pre-treatment of lapatinib in Swiss mice.

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Study of human neurovegetative and hematologic effects of environmental low-frequency (50-Hz) electromagnetic fields produced by transformers.

The exposed population had a significant increase in degree of certain neurovegetative disorders, and the population experienced a significant fall in total lymphocytes and CD4, CD3, and CD2 lymphocytes, as well as a rise in NK cells.
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MDR-1 C3435T Polymorphism Influences Cyclosporine A Dose Requirement in Liver-Transplant Recipients

It is demonstrated that the MDR1 exon 26 C3435T polymorphism is a major determinant of CsA concentration/dose ratio in liver-transplant recipients and is predictive of the dose ofCsA to be administered to achieve the target C2 concentration.
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Correlation between clinical response to sorafenib in hepatocellular carcinoma treatment and polymorphisms of P-glycoprotein (ABCB1) and of breast cancer resistance protein (ABCG2): monocentric study

Heterozygous forms of the studied polymorphisms could be associated with a better therapeutic response in patients with advanced HCC treated with a single agent sorafenib, and in heterozygous patients for ABCB1 3435 C>T, ABCG2 34 G>A and ABCG 2 1143 C>.T polymorphisms were significantly associated with the lowest sorafinib plasma levels.
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SYMPTOMS EXPERIENCED BY USERS OF DIGITAL CELLULAR PHONES: A STUDY OF A FRENCH ENGINEERING SCHOOL

Digital cellular phone users more often complained of discomfort, warmth, and pricking of the ear during phone conversations as a function of calling duration per day and number of calls per day.
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Alterations of biological parameters in mice chronically exposed to low-frequency (50 Hz) electromagnetic fields.

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Association between ABCB1 C3435T polymorphism and increased risk of cannabis dependence

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Therapy with boceprevir or telaprevir in HIV/hepatitis C virus co-infected patients to treat recurrence of hepatitis C virus infection after liver transplantation

The data suggest that in HIV/HCV co-infected patients, triple anti-HCV therapy with telaprevir greatly improved efficacy despite poor tolerability.
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