• Publications
  • Influence
Microfluidic scaffolds for tissue engineering.
Most methods to culture cells in three dimensions depend on a cell-seedable biomaterial to define the global structure of the culture and the microenvironment of the cells. Efforts to tailor theseExpand
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Comparison of Chondrogensis in Static and Perfused Bioreactor Culture
As a result of the low yield of cartilage from primary patient harvests and a high demand for autologous cartilage for reconstructive surgery and structural repair, primary explant cartilage must beExpand
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The effect of dynamic compression on the response of articular cartilage to insulin‐like growth factor‐I
Articular cartilage is routinely subjected to mechanical forces and to cell‐regulatory molecules. Previous studies have shown that mechanical stimuli can influence articular chondrocyte metabolicExpand
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Direct freeform fabrication of seeded hydrogels in arbitrary geometries.
A major challenge in tissue engineering is the generation of cell-seeded implants with structures that mimic native tissue, both in anatomic geometries and intratissue cell distributions. ByExpand
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Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior.
Numerous studies have described the effects of matrix stiffening on cell behavior using two-dimensional synthetic surfaces; however, less is known about the effects of matrix stiffening on cellsExpand
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Tissue-Engineered Composites of Anulus Fibrosus and Nucleus Pulposus for Intervertebral Disc Replacement
Study Design. By the technique of tissue engineering, composite intervertebral disc implants were fabricated as novel materials for disc replacement, implanted into athymic mice, and removed at timesExpand
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Temporal bone fractures: otic capsule sparing versus otic capsule violating clinical and radiographic considerations.
OBJECTIVE To assess the practicality and utility of the traditional classification system for temporal bone fracture (transverse vs. longitudinal) in the modern Level I trauma setting and toExpand
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Measurement of local strains in intervertebral disc anulus fibrosus tissue under dynamic shear: contributions of matrix fiber orientation and elastin content.
Shear strain has been implicated as an initiator of intervertebral disc anulus failure, however a clear, multi-scale picture of how shear strain affects the tissue microstructure has been lacking.Expand
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High-resolution spatial mapping of shear properties in cartilage.
Structural properties of articular cartilage such as proteoglycan content, collagen content and collagen alignment are known to vary over length scales as small as a few microns (Bullough andExpand
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Dense type I collagen matrices that support cellular remodeling and microfabrication for studies of tumor angiogenesis and vasculogenesis in vitro.
Type I collagen is a favorable substrate for cell adhesion and growth and is remodelable by many tissue cells; these characteristics make it an attractive material for the study of dynamic cellularExpand
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