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Cox-2 inhibitory effects of naturally occurring and modified fatty acids.
TLDR
This study shows that several of the natural fatty acids as well as all of the semisynthetic thioether-containing fatty acids inhibited COX-2-catalyzed prostaglandin biosynthesis, where alpha-LNA and compound 2 showed selectivity toward COx-2.
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Antifouling activity of brominated cyclopeptides from the marine sponge Geodia barretti.
TLDR
The potent antifouling effects of two compounds isolated from the marine sponge Geodia barretti are shown, hypothesize that the isolated compounds are part of the sponge's chemical defense to deter fouling organisms.
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Antifouling Activity of Bromotyrosine-Derived Sponge Metabolites and Synthetic Analogues
TLDR
It is hypothesized that the brominated sponge-derived metabolites and synthetic analogues analyzed for antilarval settlement of Balanus improvisus needs to cross membranes (probably by diffusion) and that the target for psammaplin A lies intracellularly.
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Cyclotides: a novel type of cytotoxic agents.
TLDR
Activity profiles of the cyclotides differed significantly from those of antitumor drugs in clinical use, which may indicate a new mode of action in cytotoxic activities of naturally occurring macrocyclic peptides isolated from the two violets.
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Biosynthesis, natural sources, dietary intake, pharmacokinetic properties, and biological activities of hydroxycinnamic acids.
TLDR
The chemistry, biosynthesis, natural sources, dietary intake, and pharmacokinetic properties of hydroxycinnamic acids are discussed.
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Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis.
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Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.
TLDR
The optimization procedure resulted in a considerable reduction of the amount of enzyme required for adequate prostglandin biosynthesis and a reliable method suited to evaluate natural products on inhibition of COX-2-catalyzed prostagland in biosynthesis, as well as onCOX-1.
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Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
TLDR
A rapid semi-homogeneous cyclooxygenase-2 (COX-2) enzymatic assay using scintillation proximity assay (SPA) technology was developed, and 49 ubiquitous plant secondary metabolites were screened for inhibition of COx-2-catalyzed prostaglandin E(2) (PGE(2)) biosynthesis, finding eugenol, pyrogallol, and cinnamaldehyde were found to inhibit COX- 2.
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Small, novel proteins from the mistletoe Phoradendron tomentosum exhibit highly selective cytotoxicity to human breast cancer cells
TLDR
Four novel proteins (phoratoxins C–F) have been isolated from the North American mistletoe Phoradendron tomentosum, and the most potent cytotoxic phoratoxin C was further tested on primary cultures of human tumor cells from patients.
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Seven novel macrocyclic polypeptides from Viola arvensis.
TLDR
Seven novel macrocyclic polypeptides, designated as varv peptides B-H, have been isolated from the aerial parts of Viola arvensis and exhibited high degrees of homology with the hitherto known macro cyclic peptides.
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