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- Publications
- Influence
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.
- T. Ringbom, U. Huss, +4 authors L. Bohlin
- Chemistry, Medicine
- Journal of natural products
- 24 May 2001
In the search for new cyclooxygenase-2 (COX-2) selective inhibitors, the inhibitory effects of naturally occurring fatty acids and some of their structural derivatives on COX-2-catalyzed… Expand
Cyclotides: a novel type of cytotoxic agents.
- P. Lindholm, U. Göransson, +5 authors A. Backlund
- Biology, Medicine
- Molecular cancer therapeutics
- 1 April 2002
Cytotoxic activities of three naturally occurring macrocyclic peptides (cyclotides) isolated from the two violets, Viola arvensis Murr. and Viola odorata L., were investigated. A nonclonogenic… Expand
Biosynthesis, natural sources, dietary intake, pharmacokinetic properties, and biological activities of hydroxycinnamic acids.
- H. El-Seedi, Asmaa M. el-Said, +4 authors R. Verpoorte
- Chemistry, Medicine
- Journal of agricultural and food chemistry
- 30 October 2012
Hydroxycinnamic acids are the most widely distributed phenolic acids in plants. Broadly speaking, they can be defined as compounds derived from cinnamic acid. They are present at high concentrations… Expand
Antifouling activity of brominated cyclopeptides from the marine sponge Geodia barretti.
- M. Sjögren, U. Göransson, +5 authors L. Bohlin
- Chemistry, Medicine
- Journal of natural products
- 5 February 2004
In this work, we show the potent antifouling effects of two compounds, barettin (cyclo[(6-bromo-8-entryptophan)arginine]) (1), isolated as a Z/E mixture (87/13), and 8,9-dihydrobarettin… Expand
Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis.
- H. Tunón, C. Olavsdotter, L. Bohlin
- Biology, Medicine
- Journal of ethnopharmacology
- 1 October 1995
Plants used in Swedish traditional medicine to treat inflammatory diseases and/or wounds were selected, based on literature data, for evaluation of inhibitory activity on prostaglandin biosynthesis… Expand
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
- U. Huss, T. Ringbom, P. Perera, L. Bohlin, M. Vasänge
- Chemistry, Medicine
- Journal of natural products
- 11 September 2002
A rapid semi-homogeneous cyclooxygenase-2 (COX-2) enzymatic assay using scintillation proximity assay (SPA) technology was developed, and 49 ubiquitous plant secondary metabolites were screened for… Expand
Antifouling Activity of Bromotyrosine-Derived Sponge Metabolites and Synthetic Analogues
- Sofia Ortlepp, M. Sjögren, +7 authors P. Proksch
- Biology, Medicine
- Marine Biotechnology
- 23 August 2007
Eighteen brominated sponge-derived metabolites and synthetic analogues were analyzed for antilarval settlement of Balanus improvisus. Only compounds exhibiting oxime substituents including bastadin-3… Expand
Seven novel macrocyclic polypeptides from Viola arvensis.
- U. Göransson, T. Luijendijk, S. Johansson, L. Bohlin, P. Claeson
- Chemistry, Medicine
- Journal of natural products
- 26 January 1999
Seven novel macrocyclic polypeptides, designated as varv peptides B-H, have been isolated from the aerial parts of Viola arvensis. Their primary structures have been elucidated by automated Edman… Expand
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.
- Y. Noreen, T. Ringbom, P. Perera, H. Danielson, L. Bohlin
- Chemistry, Medicine
- Journal of natural products
- 1998
A radiochemical enzyme assay for studying cyclooxygenase (COX)-catalyzed prostaglandin biosynthesis in vitro was optimized with respect to both COX-1 and COX-2 activity. The assay can be used to… Expand
Functional versus chemical diversity: is biodiversity important for drug discovery?
- Martin Tulp, L. Bohlin
- Biology, Medicine
- Trends in pharmacological sciences
- 1 May 2002
Prospecting the full biodiversity of nature to find leads for new drugs is not necessary. Because finding leads is aimed at identifying biological activity, structure is of secondary importance.… Expand