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Serum and plasma BDNF levels in major depression: A replication study and meta-analyses
TLDR
Evidence of peripheral BDNF alteration in MD is provided and support the rationale for further investigation aiming to the identification of biomarkers for differential diagnosis and personalization of therapies in this disorder.
Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases
TLDR
The results support the role of BDNF alterations in neurodegenerative mechanisms common to different forms of neurological disorders and underline the importance of including drug treatment in the analyses to avoid confounding effects.
VEGF serum levels in depressed patients during SSRI antidepressant treatment
Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment.
TLDR
The results indicate that BDNF serum modulation observed in depressed patients is associated with BDNF synthesis alteration in leukocytes and suggest that these peripheral cells might play an active role in the mechanisms of action of antidepressants.
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