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Metabolic functions of duplicate genes in Saccharomyces cerevisiae.
The roles of duplicate genes and their contribution to the phenomenon of enzyme dispensability are a central issue in molecular and genome evolution. A comprehensive classification of the mechanismsExpand
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Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast
BackgroundQuantification of intracellular metabolite fluxes by 13C-tracer experiments is maturing into a routine higher-throughput analysis. The question now arises as to which mutants should beExpand
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Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts.
In a quantitative comparative study, we elucidated the glucose metabolism in fourteen hemiascomycetous yeasts from the Genolevures project. The metabolic networks of these different species wereExpand
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Microbial hyaluronic acid production
AbstractsHyaluronic acid (HA) is a commercially valuable medical biopolymer increasingly produced through microbial fermentation. Viscosity limits product yield and the focus of research andExpand
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Growth independent rhamnolipid production from glucose using the non-pathogenic Pseudomonas putida KT2440
BackgroundRhamnolipids are potent biosurfactants with high potential for industrial applications. However, rhamnolipids are currently produced with the opportunistic pathogen Pseudomonas aeruginosaExpand
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Carbon metabolism limits recombinant protein production in Pichia pastoris
The yeast Pichia pastoris enables efficient (high titer) recombinant protein production. As the molecular tools required are well established and gene specific optimizations of transcription andExpand
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Metabolic capacity estimation of Escherichia coli as a platform for redox biocatalysis: constraint‐based modeling and experimental verification
Whole‐cell redox biocatalysis relies on redox cofactor regeneration by the microbial host. Here, we applied flux balance analysis based on the Escherichia coli metabolic network to estimate maximalExpand
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Response of Pseudomonas putida KT2440 to Increased NADH and ATP Demand†
ABSTRACT Adenosine phosphate and NAD cofactors play a vital role in the operation of cell metabolism, and their levels and ratios are carefully regulated in tight ranges. Perturbations of theExpand
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Prospecting the biodiversity of the fungal family Ustilaginaceae for the production of value-added chemicals
BackgroundUstilaginaceae (belonging to the smut fungi) are commonly known for their plant pathogenicity. Although these microbes lead to yield reduction of cereal production, they can also have anExpand
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Genetic and biochemical insights into the itaconate pathway of Ustilago maydis enable enhanced production.
The Ustilaginaceae family of smut fungi, especially Ustilago maydis, gained biotechnological interest over the last years, amongst others due to its ability to naturally produce the versatileExpand
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