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Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL‐37
Effectors of the innate immune system, the anti‐bacterial peptides, have pivotal roles in preventing infection at epithelial surfaces. Here we show that proteinases of the significant human pathogensExpand
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MtsABC Is Important for Manganese and Iron Transport, Oxidative Stress Resistance, and Virulence of Streptococcus pyogenes
ABSTRACT MtsABC is a Streptococcus pyogenes ABC transporter which was previously shown to be involved in iron and zinc accumulation. In this study, we showed that an mtsABC mutant has impairedExpand
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Purification and some properties of streptococcal protein G, a novel IgG-binding reagent.
Protein G, a bacterial cell wall protein with affinity for immunoglobulin G (IgG), has been isolated from a human group G streptococcal strain (G148). Bacterial surface proteins were solubilized byExpand
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Protein SIC, a Novel Extracellular Protein of Streptococcus pyogenes Interfering with Complement Function (*)
The human pathogen Streptococcus pyogenes possesses a chromosomal region, the mga regulon, that contains co-regulated genes important to the virulence of these bacteria. A novel gene located in theExpand
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Protein L. A novel bacterial cell wall protein with affinity for Ig L chains.
  • L. Björck
  • Chemistry, Medicine
  • Journal of immunology
  • 15 February 1988
A novel Ig-binding protein has been isolated from the surface of bacteria belonging to the anaerobic species Peptococcus magnus. To solubilize the protein, peptococci were treated with differentExpand
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IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G
Recent work from several laboratories has demonstrated that proteolytic mechanisms significantly contribute to the molecular interplay between Streptococcus pyogenes, an important human pathogen, andExpand
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M Protein, a Classical Bacterial Virulence Determinant, Forms Complexes with Fibrinogen that Induce Vascular Leakage
Increased vascular permeability is a key feature of inflammatory conditions. In severe infections, leakage of plasma from the vasculature induces a life-threatening hypotension. StreptococcusExpand
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SclA, a Novel Collagen-Like Surface Protein ofStreptococcus pyogenes
ABSTRACT Surface proteins of Streptococcus pyogenes are important virulence factors. Here we describe a novel collagen-like surface protein, designated SclA (streptococcal collagen-like surfaceExpand
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Virulent aggregates of Streptococcus pyogenes are generated by homophilic protein–protein interactions
Many strains of the important human pathogen Streptococcus pyogenes form aggregates when grown in vitro in liquid medium. The present studies demonstrate that this property is crucial for theExpand
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Identification and characterization of a Streptococcus pyogenes ABC transporter with multiple specificity for metal cations
Metal ions are crucial trace elements for bacteria infecting the human host. The LraI (lipoprotein receptor‐associated antigen I) transporter in Streptococcus spp. belongs to the superfamily of ABCExpand
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