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Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats.
cAMP/cAMP-dependent protein kinase (PKA) signaling pathway has been recently proposed to participate in both the late phase of long term potentiation in the hippocampus and in the late, proteinExpand
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Dopamine Controls Persistence of Long-Term Memory Storage
Making Memories Last How can memory traces persist over days or weeks, despite the short-lived nature and rapid turnover of their molecular substrates? It has recently been reported that, in order toExpand
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On the role of hippocampal protein synthesis in the consolidation and reconsolidation of object recognition memory.
Upon retrieval, consolidated memories are again rendered vulnerable to the action of metabolic blockers, notably protein synthesis inhibitors. This has led to the hypothesis that memories areExpand
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Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade.
It is widely accepted that the formation of long-term memory (LTM) requires neuronal gene expression, protein synthesis and the remodeling of synaptic contacts. From mollusk to mammals, theExpand
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Different molecular cascades in different sites of the brain control memory consolidation
To understand cognition, it is important to understand how a learned response becomes a long-lasting memory. This process of memory consolidation has been modeled extensively using one-trialExpand
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Retrieval induces hippocampal-dependent reconsolidation of spatial memory.
Nonreinforced retrieval can cause extinction and/or reconsolidation, two processes that affect subsequent retrieval in opposite ways. Using the Morris water maze task we show that, in the rat,Expand
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On the participation of mTOR in recognition memory
Evidence indicates that activation of the neuronal protein synthesis machinery is required in areas of the brain relevant to memory for consolidation and persistence of the mnemonic trace. Here, weExpand
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Angiotensin II disrupts inhibitory avoidance memory retrieval
The brain renin-angiotensin system (RAS) is involved in learning and memory, but the actual role of angiotensin II (A(II)) and its metabolites in this process has been difficult to comprehend. ThisExpand
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Gastrin-releasing peptide receptor antagonist effects on an animal model of sepsis.
RATIONALE Several new therapeutic strategies have been described for the treatment of sepsis, but to date none are related to alterations in the bombesin/gastrin-releasing peptide (GRP) receptorExpand
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Inhibition of hippocampal Jun N‐terminal kinase enhances short‐term memory but blocks long‐term memory formation and retrieval of an inhibitory avoidance task
Learning initiates a series of plastic events the occurrence of which are required for the storage of information related to the training experience. Several lines of evidence indicate that, in theExpand
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