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Mammary Tumors in HER-2/NEU Mice Are Characterized by Low Content of Estrogen Receptors-α and Absence of Progesterone Receptors
Transgenic mice carrying erbB2(HER-2)neu gene are characterized by high incidence of mammary adenocarcinoma. The content of estrogen receptor was no more than 10 fmol/mg protein in 8 of 14 studiedExpand
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[Aromatase activity in human muscle tissue].
Activity of aromatase (estrogen synthetase) was investigated in muscle tissue of 14 women and 2 men. The method of hard water release from androgenic precursor 3H-beta-androstendione was used. In menExpand
  • 5
[The nature of hyperinsulinemia (insulin resistance) in endometrial carcinoma: of plasma levels of insulin and c-peptide].
Standard glucose-tolerance test (SGTT) was carried out in 73 patients with endometrial tumors. Elevated concentrations of plasma insulin and C-peptide were established in endometrial carcinomaExpand
  • 6
Expression of estrogen receptors-α and -β in primary breast neoplasms and tumors exposed to neoadjuvant hormonal therapy
We studied the content and expression of mRNA for estrogen receptors receptors-α and -β in breast tumors before and after 3-month neoadjuvant hormone therapy with antiestrogen tamoxifen and/orExpand
  • 6
[Neoadjuvant use of the aromatase inhibitor letrozole in uterine cancer: endocrine and clinical effects].
Endometrial cancer (EC) is estrogen-dependent tumor in the hormonal treatment of which mostly progestins are used. During last 5-7 years feasibility of aromatase inhibitors use in EC is discussedExpand
  • 4
Content of 8-Hydroxy-2-Deoxyguanosine in Steroid Receptor-Positive and Receptor-Negative Breast Cancer Cells
The content of DNA damage marker 8-hydroxy-2-deoxyguanosine in 16 receptor-negative and 18 receptor-positive human breast neoplasms was measured by immunohistochemical methods. Positive staining wasExpand
  • 5
Induction of the Estrogen Effect-Switching Phenomenon by Ethanol and Its Correction
Female rats (aged three months at the start of the study) were kept for four months on drinking water (group 1) or 5% ethanol. Rats drinking ethanol were additionally divided into six groups (groupsExpand
  • 3
[Breast cancer receptor status in smoking and diabetic patients].
Estrogen (ER) and progesterone (PR) receptor levels were assayed in 2,284 primary breast cancer patients who either smoked (350) or suffered diabetes mellitus type 2 (1997-2003). In a group of 1010,Expand
  • 2
Expression of estrogen receptors-alpha and -beta in primary breast neoplasms and tumors exposed to neoadjuvant hormonal therapy.
We studied the content and expression of mRNA for estrogen receptors-alpha and -beta in breast tumors before and after 3-month neoadjuvant hormone therapy with antiestrogen tamoxifen and/or aromataseExpand
  • 2