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Translokin is an intracellular mediator of FGF-2 trafficking
Basic fibroblast growth factor (bFGF or FGF-2) exerts its pleiotropic activities both as an exogenous and an intracellular factor. FGF-1 and FGF-2 are prototypes for this dual signalling, but theExpand
Antiangiogenic Properties of Fibstatin, an Extracellular FGF-2–Binding Polypeptide
By using the two-hybrid system with basic fibroblast growth factor (FGF-2) as bait, we isolated and characterized fibstatin, an endogenous Mr 29,000 human basement membrane-derived inhibitor ofExpand
Ocular cell transfection with the human basic fibroblast growth factor gene delays photoreceptor cell degeneration in RCS rats.
Based on the K8/JTS-1-mediated transfection technique, we developed an in vivo protocol for an efficient transfer of plasmid DNA to ocular cells. As determined with condensed plasmids containingExpand
The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression
The tumour suppressor p53, involved in DNA repair, cell cycle arrest and apoptosis, also inhibits blood vessel formation, that is, angiogenesis, a process strongly contributing to tumour development.Expand
In vivo adenovirus-mediated delivery of a uPA/uPAR antagonist reduces retinal neovascularization in a mouse model of retinopathy
Diabetic retinopathy and retinopathy of prematurity are among the leading causes of vision impairment throughout the world. Both diseases are characterized by pathological angiogenesis, whichExpand
On a new coccidium, Eimeria raiarum sp.n., with special reference to the biology of the oocysts
During my stay at the Zoological Station of Wimereux, Pas de Calais, France, in August 1934, I made a special study of Protozoa parasitic in marine fishes. The examination of ten specimens of youngExpand
Identification of novel genes and altered signaling pathways in the retinal pigment epithelium during the Royal College of Surgeons rat retinal degeneration
Shed photoreceptor outer segments (POS) are phagocytosed by RPE cells in a circadian manner. The homozygous deletion of the c-mer gene abolishes the ingestion phase of this phagocytosis in the RoyalExpand
A Morphological Study of Bovine Schistosomes
In a memoir on human and animal schistosomiasis (1934c), I reported the presence of bovine schistosomes for the first time in the Belgian Congo (Elisabethville). I also expressed the opinion that theExpand
Efficient gene transfer in skeletal muscle with AAV-derived bicistronic vector using the FGF-1 IRES
IRESs (internal ribosome entry sites) are RNA elements behaving as translational enhancers in conditions of global translation blockade. IRESs are also useful in biotechnological applications as theyExpand