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GAP-43: an intrinsic determinant of neuronal development and plasticity
TLDR
In transgenic mice, overexpression of GAP-43 leads to the spontaneous formation of new synapses and enhanced sprouting after injury, and the protein might play an important role in mediating experience-dependent plasticity. Expand
Lens Injury Stimulates Axon Regeneration in the Mature Rat Optic Nerve
TLDR
Macrophage activation appears to play a key role, because intraocular injections of Zymosan, a yeast cell wall preparation, stimulated monocytes in the absence of lens injury and induced RGCs to regenerate their axons into the distal optic nerve. Expand
Macrophage-Derived Factors Stimulate Optic Nerve Regeneration
TLDR
It is shown here that factors secreted by macrophages stimulate RGCs to regenerate their axons, and the effects of macrophage activation can be optimized by the timing of their activation. Expand
NgR1 and NgR3 are Receptors for Chondroitin Sulfate Proteoglycans
TLDR
Nogo receptor triple mutants showed enhanced axonal regeneration following retro-orbital optic nerve crush injury, and it is found that NgR1 and NgR3 bind with high affinity to the glycosaminoglycan moiety of proteoglycans and participate in CSPG inhibition in cultured neurons. Expand
Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells
TLDR
Oncomodulin is a new growth factor for neurons of the mature central and peripheral nervous systems and stimulates more extensive outgrowth than other known trophic agents. Expand
Tumor Necrosis Factor-α Mediates Oligodendrocyte Death and Delayed Retinal Ganglion Cell Loss in a Mouse Model of Glaucoma
Glaucoma is a widespread ocular disease characterized by a progressive loss of retinal ganglion cells (RGCs). Previous studies suggest that the cytokine tumor necrosis factor-α (TNF-α) may contributeExpand
Organization of the tectofugal visual pathway in the pigeon: A retrograde transport study
TLDR
To examine the detailed organization of this principal ascending visual pathway, small injections of the marker horseradish peroxidase were placed in various sites throughout the ectostriatum (E) or nucleus rotundus (Rt) in pigeons, indicating the tectofugal pathway to be comprised of at least five different channels. Expand
Switching Mature Retinal Ganglion Cells to a Robust Growth State In Vivo: Gene Expression and Synergy with RhoA Inactivation
TLDR
The results show that, with appropriate stimulation, mature CNS neurons can undergo dramatic changes in gene expression comparable with those seen in regenerating neurons of the PNS, and that RhoA inactivation by itself results in moderate regeneration, and strongly potentiates axon regeneration through the mature optic nerve when the growth state of neurons is activated. Expand
Long-Distance Axon Regeneration in the Mature Optic Nerve: Contributions of Oncomodulin, cAMP, and pten Gene Deletion
TLDR
It is shown that the induction of a controlled inflammatory response in the eye, when combined with elevation of intracellular cAMP and deletion of the gene encoding pten, enables RGCs to regenerate axons the full length of the optic nerve in mature mice. Expand
A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program
TLDR
This work used a comprehensive systems biology approach, starting with gene expression profiling of dorsal root ganglia (DRGs) combined with multi-level bioinformatic analyses and experimental validation of network predictions, to identify a drug that accelerates DRG neurite out growth in vitro and optic nerve outgrowth in vivo by inducing elements of the identified network. Expand
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