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Astrocyte‐derived interleukin‐6 promotes specific neuronal differentiation of neural progenitor cells from adult hippocampus
TLDR
The results suggest that astrocyte‐derived IL‐6 may facilitate AHPC neuronal differentiation and have important implications for understanding injury‐induced neurogenesis and developing cell‐based therapeutic strategies using neural progenitors.
Effects of dexamethazone on LPS‐induced activationand migration of mouse dendritic cells revealed by a genome‐wide transcriptional analysis
TLDR
A genome‐wide analysis of differentially expressed genes of DC treated with Dex alone, LPS alone, or both, using high‐density oligonucleotide microarrays observed a synergistic effect of Dex and LPS on the expression of the secreted lipocalin 24p3, which has been reported to induce apoptosis in T cells and thus may be related to immune suppression.
High expression in involuting reproductive tissues of uterocalin/24p3, a lipocalin and acute phase protein.
TLDR
It is proposed that the role of uterocalin during involution is to provide a window of time during which resident cells are protected from the degradative enzymes, free radicals and other secreted products of activated phagocytes to allow these cells to prepare to survive the processes of involution.
Live-cell imaging of Pol II promoter activity to monitor gene expression with RNA IMAGEtag reporters
TLDR
The IMAGEtag RNA reporter system provides a means of tracking changes in transcriptional activity in live cells and in real time by using strings of RNA aptamers that constitute IMAGEtags (Intracellular MultiAptamer GEnetic tags) that can be expressed from a promoter of choice.
A pilot study evaluating the perceptions of Certified Registered Nurse Anesthetists toward human patient simulation.
TLDR
An evaluation was conducted of perceptions of practicing Certified Registered Nurse Anesthetists toward use of simulation for initial certification, continuing education, and recertification, and there was consensus that human patient simulation is an important part of anesthesia provider training.
Tissue Involution and the Acute Phase Response
TLDR
The ability of uterocalin to induce apoptosis in neutrophils might also decrease oxidative and carcinogenic activity in the gland and result in a lower mutation rate and thus a lower probability of cancer in the primiparous gland.
Creating metamaterial building blocks with directed photochemical metallization of silver onto DNA origami templates.
TLDR
A method for creating metal-coated nanostructures using DNA origami templates and a photochemical metallization technique, which results in a metal nanostructure that maps the shape of the original DNA template with a continuous and uniform metal layer and stops growing once all available DNA sites are exhausted.
Lipocalin-2-loaded Amphiphilic Polyanhydride Microparticles Accelerate Cell Migration
TLDR
It is demonstrated that amphiphilic polyanhydride microparticles based on co-polymers of 1,6-bis(p-carboxyphenoxy)hexane (CPH) and 1, 6-bis (p- carboxyhenoxy)-3,6 -dioxaoctanes (CPTEG) provide stabilizing environments for proteins to facilitate therapeutic use of protein/drug carriers.
Aptamer-enabled uptake of small molecule ligands
TLDR
It is shown here that, when expressed in cells, aptamers can increase the intracellular concentrations of their small molecule ligands, and are named as DRAGINs (Drug Binding Aptamers for Growing Intracellular Numbers) by assessing the ability to enhance the toxicity of their ligands.
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