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Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model.
Reversible MCAo in which a poly-L-lysine-coated intraluminal suture was used proved to be a reliable and effective modification of this technique, yielding consistently larger infarcts and greatly reduced interanimal variability.
Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats
Middle cerebral artery occlusion in the mouse by intraluminal suture coated with poly-l-lysine: neurological and histological validation
Robust Docosahexaenoic Acid–Mediated Neuroprotection in a Rat Model of Transient, Focal Cerebral Ischemia
It is concluded that DHA experimental therapy at low and medium doses improves neurologic and histologic outcomes after focal cerebral ischemia and might provide benefits in patients after ischemic stroke.
Transient Middle Cerebral Artery Occlusion by Intraluminal Suture: I. Three-Dimensional Autoradiographic Image-Analysis of Local Cerebral Glucose Metabolism—Blood Flow Interrelationships during…
- L. Belayev, Weizhao Zhao, R. Busto, M. Ginsberg
- Medicine, BiologyJournal of cerebral blood flow and metabolism…
- 1 December 1997
Regression analysis indicated that depressed glucose utilization in a highly reproducible model of transient middle cerebral artery occlusion for 2 hours induced graded LCBF decrements affecting ipsilateral cortical and basal ganglionic regions, and was determined largely by the intensity of antecedent ischemia.
Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke
Experimental intracerebral hemorrhage in the mouse: histological, behavioral, and hemodynamic characterization of a double-injection model.
The present ICH model in mice produces a consistent neurological deficit, hypoperfusion, hematoma volume, and brain swelling and should be useful for the evaluation of pharmaceutical therapies.
Albumin Therapy of Transient Focal Cerebral Ischemia: In Vivo Analysis of Dynamic Microvascular Responses
These results reveal a beneficial effect of albumin therapy in reversing stagnation, thrombosis, and corpuscular adherence within cortical venules in the reperfusion phase after focal ischemia and support its utility in the treatment of acute ischemic stroke.
Transient Middle Cerebral Artery Occlusion by Intraluminal Suture: II. Neurological Deficits, and Pixel-Based Correlation of Histopathology with Local Blood Flow and Glucose Utilization
- Weizhao Zhao, L. Belayev, M. Ginsberg
- MedicineJournal of cerebral blood flow and metabolism…
- 1 December 1997
A pixel-based analysis of the acute hemodynamic and metabolic determinants of infarctive histopathology in a reproducible model of temporary middle cerebral artery occlusion in rats indicates that local blood flow at 2 hours of MCAO is a robust predictor of eventual infarction.
Docosahexaenoic Acid Signaling Modulates Cell Survival in Experimental Ischemic Stroke Penumbra and Initiates Long-Term Repair in Young and Aged Rats
- Tiffany N. Eady, L. Belayev, Larissa Khoutorova, Kristal D. Atkins, Chang-yuan Zhang, N. Bazan
- Biology, MedicinePloS one
- 30 October 2012
DHA induces cell survival, modulates the neuroinflammatory response and triggers long term restoration of synaptic circuits, which suggests activation of DHA signaling might provide benefits in the management of ischemic stroke both acutely as well as long term to limit ensuing disabilities.