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Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder
TLDR
A model is presented which describes how frontal-subcortical brain circuitry may mediate OCD symptomatology, and a hypothesis for how successful treatments may ameliorate symptoms, via their effects on circuit activity is suggested.
Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder.
TLDR
Right orbital cortex/hem was significantly correlated with ipsilateral Cd/hem and thalamus/hem before treatment but not after, and the differences before and after treatment were significant, suggesting a brain circuit involving these brain regions may mediate obsessive-compulsive disorder symptoms.
Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings.
TLDR
Subjects with MDD had regional brain metabolic abnormalities at baseline that tended to normalize with treatment, and regional metabolic changes appeared similar with the 2 forms of treatment.
Brain metabolic changes during cigarette craving.
TLDR
Brain regions associated with arousal, compulsive repetitive behaviors, sensory integration, and episodic memory are activated during exposure to cigarette-related cues and cigarette craving, similar to findings with other addictive substances.
Reduction of prefrontal cortex glucose metabolism common to three types of depression.
Using positron emission tomography, we studied cerebral glucose metabolism in drug-free, age- and sex-matched, right-handed patients with unipolar depression (n = 10), bipolar depression (n = 10),
Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive-compulsive disorder.
TLDR
Findings in this study replicate and extend previous findings of changes in caudate nucleus function with behavior therapy for obsessive-compulsive disorder.
Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression.
TLDR
Findings suggest that, although both OCD and major depressive disorder respond to SRIs, the two syndromes have different neurobiological substrates for response.
Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls.
TLDR
In OCD, metabolic rates were significantly increased in the left orbital gyrus and bilaterally in the caudate nuclei, and cerebral glucose metabolic patterns that differed from controls in both the symptomatic and recovered states.
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