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Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats
These findings support previous reports indicating that the discriminative stimulus effects of salvinorin A are mediated by kappa receptors, and future studies may assist in the development and screening of salvinegorin A analogs for potential pharmacotherapy.
MDMA and Learning Effects of Acute and Neurotoxic Exposure in the Rat
A three-choice discrimination procedure dissociates the discriminative stimulus effects of d-amphetamine and (+/-)-MDMA in rats.
This study successfully used a 3-choice operant procedure to establish MDMA and d-amphetamine as discriminative stimuli in rats and found that cocaine, Cocaine, and LSD produced dose-dependent increases in MDMA-appropriate responding with nearly complete substitution for MDMA.
Sensitization to the locomotor stimulant effects of "bath salt" constituents, 4-methylmethcathinone (4-MMC) and 3,4-methylenedioxypyrovalerone (MDPV), in male Sprague-Dawley rats.
Assessment of the MDA and MDMA Optical Isomers in a Stimulant-Hallucinogen Discrimination
Reinforcement schedule effects in rats trained to discriminate 3,4-methylenedioxymethamphetamine (MDMA) or cocaine
The present findings suggest that the number of sessions required to establish discriminative stimulus control varies with different reinforcement schedules, and training schedules alone do not appear to have significant effects on stimulus generalization between MDMA and cocaine.
Serotonergic–dopaminergic mediation of MDMA's discriminative stimulus effects in a three-choice discrimination
Differential effects of 3,4-methylenedioxypyrovalerone (MDPV) and 4-methylmethcathinone (mephedrone) in rats trained to discriminate MDMA or a d-amphetamine + MDMA mixture
These findings indicate that MDPV’s effects may be more similar to those of traditional psychostimulants, whereas MEPH exerts stimulus effects more similar than those of MDMA.
Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) and its metabolic precursor, gamma-butyrolactone (GBL) in rats
- L. Baker, Timothy J. Van Tilburg, A. Brandt, A. Poling
- Biology, PsychologyPsychopharmacology
- 6 July 2005
These findings suggest that GHB and its metabolic precursors produce similar subjective effects that differ from those of other sedative-hypnotic drugs.
The role of monoamine uptake in the discriminative stimulus effects of cocaine and related compounds1
- L. Baker, E. Riddle, R. Saunders, J. B. Appel
- Psychology, BiologyBehavioural pharmacology
- 1 February 1993
Results reported previously suggest that inhibition of DA uptake is involved to a greater extent than either NE or 5-HT uptake in the discriminative stimulus properties of cocaine and related compounds.