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Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer.
G-quadruplexes are non-canonical DNA secondary structures putatively present in the promoter regions of oncogenes in the human genome. The targeting of promoter G-quadruplex structures to repressExpand
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DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine.
A comparative study on the intercalating binding of sanguinarine, chelerythrine, and nitidine with CT DNA, poly(dG-dC).poly(dG-dC), poly(dA-dT).poly(dA-dT), and seven sequence-designedExpand
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The in Vitro Structure-Related Anti-Cancer Activity of Ginsenosides and Their Derivatives
Panax ginseng has long been used in Asia as a herbal medicine for the prevention and treatment of various diseases, including cancer. The current study evaluated the cytotoxic potency against aExpand
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Dihydro-β-agarofuran sesquiterpene polyesters isolated from the stems of Tripterygium regelii.
Twelve new dihydro-β-agarofuran polyesters, triptregelines A-J (1-3 and 5-11) and triptregelols A, B (4, 12), together with five known ones (13-17) were isolated from the stems of TripterygiumExpand
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Enhanced hydrogen production from xylose and bamboo stalk hydrolysate by overexpression of xylulokinase and xylose isomerase in Klebsiella oxytoca HP1
National Nature Science Foundation of China [31170760]; Key Project of International Collaboration of Science and Technology [2009DFA60930]; Natural Science Foundation of Fujian Province of ChinaExpand
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Enhanced photo-fermentative hydrogen production from different organic substrate using hupL inactivated Rhodopseudomonas palustris.
National Nature Science Foundation of China [30870051, 31170760]; Key Project of International Collaboration of Science and Technology [2009DFA60930]; Natural Science Foundation of Fujian Province,Expand
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Crystal violet as a fluorescent switch-on probe for i-motif: label-free DNA-based logic gate.
The first application of crystal violet as a selective fluorescent switch-on probe for i-motif DNA has been reported. This interaction has been exploited to develop a label-free DNA-based "OR" logicExpand
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Comparison of in vitro antiviral activity of tea polyphenols against influenza A and B viruses and structure-activity relationship analysis.
Influenza poses a particular risk of severe outcomes in the elderly, the very young and those with underlying diseases. Tea polyphenols are the natural phenolic compounds in teas, and principallyExpand
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Overweight, Obesity and Meningioma Risk: A Meta-Analysis
Background and Objectives Studies of the association between excess body weight and risk of meningioma have produced inconsistent results. Therefore, a meta-analysis of published studies wasExpand
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Spacer length and attaching position-dependent binding of synthesized protoberberine dimers to double-stranded DNA.
Six jatrorrhizine homodimers and berberine-jatrorrhizine heterodimers have been synthesized in moderate to good yields from the reaction of jatrorrhizine with alpha,omega-dibromoalkanes andExpand
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