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Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome.
Criteria for defining asthma endotypes on the basis of their phenotypes and putative pathophysiology are suggested and how these new definitions can be used in clinical study design and drug development to target existing and novel therapies to patients most likely to benefit are proposed. Expand
International consensus on (ICON) pediatric asthma
The purpose of this document is to highlight the key messages that are common to many of the existing guidelines, while critically reviewing and commenting on any differences, thus providing a concise reference. Expand
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program.
Severe asthma is characterized by abnormal lung function that is responsive to bronchodilators, a history of sinopulmonary infections, persistent symptoms, and increased health care utilization. Expand
Classifying asthma severity in children: mismatch between symptoms, medication use, and lung function.
In children, asthma severity classified by symptom frequency and medication usage does not correlate with FEV(1) categories defined by National Asthma Education and Prevention Program Guidelines, whereas FEV (1)/FVC declines as asthma severity increases. Expand
Long-term inhaled corticosteroids in preschool children at high risk for asthma.
In preschool children at high risk for asthma, two years of inhaled-corticosteroid therapy did not change the development of asthma symptoms or lung function during a third, treatment-free year, and these findings do not provide support for a subsequent disease-modifying effect of inhaling corticosteroids after the treatment is discontinued. Expand
Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids.
LABA step-up was significantly more likely to provide the best response than either ICS or LTRA step- up, however, many children had a best response to ICSor LTRAstep-up therapy, highlighting the need to regularly monitor and appropriately adjust each child's asthma therapy. Expand
Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma.
The high prevalence of aeroallergen sensitization in this high-risk cohort suggests that aero allergens might have an important role in the early development of asthma in toddlers with episodic wheezing. Expand
Molecular mechanisms of IgE regulation.
  • L. Bacharier, R. Geha
  • Biology, Medicine
  • The Journal of allergy and clinical immunology
  • 1 February 2000
The molecular mechanisms of IL-4 and CD40 signaling that lead to IgE isotype switching are reviewed and the implications for intervening to abort or suppress the IgE antibody response are discussed. Expand
Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2
Underlying respiratory allergy and experimental allergen exposure reduce the expression of the SARS-CoV-2 receptor, ACE2, which could lead to reduced COVID-19 susceptibility.
Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial.
In pregnant women at risk of having a child with asthma, supplementation with 4400 IU/d of vitamin D compared with 400IU/d significantly increased vitamin D levels in the women, but this did not meet statistical significance; however, the study may have been underpowered. Expand