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Ceramide 1-phosphate (C1P) promotes cell migration Involvement of a specific C1P receptor.
Ceramide 1-phosphate (C1P) is a bioactive sphingolipid that is implicated in the regulation of cell homeostasis and the control of inflammation. It is mitogenic for fibroblasts and macrophages, andExpand
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Ceramide and ceramide 1-phosphate in health and disease
Sphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions ofExpand
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Activation of protein kinase C‐α is essential for stimulation of cell proliferation by ceramide 1‐phosphate
We previously demonstrated that ceramide‐1‐phosphate (C1P) stimulates fibroblast and macrophage proliferation, but the mechanisms involved in this action have only been partially described. Here weExpand
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Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs
Drug delivery systems have opened new avenues to improve the therapeutic effects of already-efficient molecules. Particularly, Solid Lipid Nanoparticles (SLNs) have emerged as promising nanocarriersExpand
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Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease.
Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial regulators of cell functions.Expand
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Involvement of nitric oxide in the promotion of cell survival by ceramide 1‐phosphate
Macrophages play vital roles in inflammatory responses, and their number at sites of inflammation is strictly regulated by cell death and division. Here, we demonstrate that production of nitricExpand
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Ceramide-1-phosphate in cell survival and inflammatory signaling.
An important metabolite of ceramide is ceramide-1-phosphate (C1P). This lipid second messenger was first demonstrated to be mitogenic for fibroblasts and macrophages and later shown to haveExpand
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Ceramide 1-phosphate stimulates glucose uptake in macrophages.
It is well established that ceramide 1-phosphate (C1P) is mitogenic and antiapoptotic, and that it is implicated in the regulation of macrophage migration. These activities require high energy levelsExpand
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Exogenous ceramide-1-phosphate (C1P) and phospho-ceramide analogue-1 (PCERA-1) regulate key macrophage activities via distinct receptors.
Inflammation is an ensemble of tightly regulated steps, in which macrophages play an essential role. Previous reports showed that the natural sphingolipid ceramide 1-phosphate (C1P) stimulatesExpand
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Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages.
We previously reported that incubation of bone-marrow derived macrophages in the absence of macrophage-colony stimulating factor (M-CSF), a cytokine that is essential for their growth and survival,Expand
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