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The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells.
TLDR
LSECtin expression in human peripheral blood and thymic dendritic cells isolated ex vivo is reported, suggesting that LSECtin participates in antigen uptake and internalization, and might be a suitable target molecule in vaccination strategies. Expand
Temporal Trends of Invasive Streptococcus pneumoniae Serotypes and Antimicrobial Resistance Patterns in Spain from 1979 to 2007
TLDR
The increase in PCV 7 serotypes and antibiotic nonsusceptibility related to antibiotic consumption in the 1980s and 1990s was reversed in the 2000s, probably as a result of PCV7 immunization, and the decrease in IPD incidence was mirrored by an increase in that of non-PCV7 serotypes. Expand
Has the licensing of respiratory quinolones for adults and the 7-valent pneumococcal conjugate vaccine (PCV-7) for children had herd effects with respect to antimicrobial non-susceptibility in
TLDR
This ecological analysis suggests that PCV-7 vaccination in children had a herd effect in adults, but consumption of respiratory quinolones in adults had no effect on pneumococcal susceptibility to levofloxacin in children. Expand
Estradiol impairs the Th17 immune response against Candida albicans
TLDR
It is proposed that estradiol impairs DC function, thus explaining the increased susceptibility to infection during estrus, and increases mouse susceptibility to systemic candidiasis. Expand
Suppression of CD4+ T Lymphocyte Activation in Vitro and Experimental Encephalomyelitis in Vivo by the Phosphatidyl Inositol 3-Kinase Inhibitor PIK-75
TLDR
PIK-75 is an efficient suppressor of EAE, modulating lymphocyte function and survival, and its effects on immune and autoimmune responses should be studied. Expand
AM3, a natural glycoconjugate, induces the functional maturation of human dendritic cells
TLDR
The effects of Inmunoferon‐active principle (AM3), the active agent of a commercial immunomodulatory drug, on human monocyte‐derived DCs (MDDCs) are investigated. Expand
T-Cell-Specific Loss of the PI-3-Kinase p110α Catalytic Subunit Results in Enhanced Cytokine Production and Antitumor Response
TLDR
PI3K p110α plays a significant role in antigen activation and differentiation of CD4+ and CD8+ T lymphocytes modulating antitumor immunity. Expand
The pathogen receptor liver and lymph node sinusoidal endotelial cell C‐type lectin is expressed in human Kupffer cells and regulated by PU.1†
TLDR
LSECtin is expressed by liver myeloid cells, and its expression is dependent on the PU.1 transcription factor, confirmed through the analysis of the proximal regulatory region of the human LSECtin gene. Expand
ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.
TLDR
In vivo, therapeutic administration of ETP-46321 significantly inhibited responses to protein antigen as well as collagen-induced arthritis, as measured by antigen-specific antibody responses, secretion of IL-10, IL-17A or IFN-γ, or clinical symptoms. Expand
Dendritic cells: still a promising tool for cancer immunotherapy
TLDR
The types and effector functions of dendritic cells in the human system are outlined, and the present state of anti-tumour immunotherapy protocols is summarised, emphasising the most relevant parameters currently evaluated in preclinical and clinical assays. Expand
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