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Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.
TLDR
It is generalized that beta-naphthoflavone induces CYP1A2 and isoniazid induces CyP2E1, whereas rifampin and, to a lesser extent phenobarbital, tend to significantly and consistently induce enzymes of the CYP2A, CYB2B, CYP 2C, CYp2E, and CYP3A subfamilies but not the 2D subfamily.
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Regulation of apical K and Na channels and Na/K pumps in rat cortical collecting tubule by dietary K
TLDR
The results suggest that SK channels, Na channels and Na/K pumps are regulated during changes in K intake by factors other than aldosterone, as well as investigating the relationship between K channel activity and mineralocorticoids.
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Regulation of Na channels of the rat cortical collecting tubule by aldosterone
TLDR
With salt depletion or furosemide injection NPo is a saturable function of aldosterone concentration with half-maximal activity at approximately 8 nM, and increases in NPo were primarily due to increases in the number of channels per patch at a constant open probability (Po).
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Regulation of the Na-K pump of the rat cortical collecting tubule by aldosterone
TLDR
The induction of channel activity in this tissue is a direct action of aldosterone, whereas the induction of pump activity may be a consequence of the increased Na traffic through the epithelial cells.
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Oxytocin and bovine parturition: a steep rise in endometrial oxytocin receptors precedes onset of labor.
TLDR
The regulation of oxytocin receptors by ovarian hormones in the two tissues may therefore differ, and the regulation of Oxytocin receptor concentrations in the three tissues may also differ.
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Pharmacokinetics and interspecies scaling of a novel VEGF receptor inhibitor, SU5416
TLDR
Using allometry, it was possible to achieve reasonable predictions of the pharmacokinetic parameters of SU5416 in cancer patients with various solid tumours, and an improved prediction of the corresponding parameters in humans was obtained when extrapolation from only the rodent data was performed.
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Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416.
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Effect of finasteride on adrenal steroidogenesis in men.
TLDR
Finasteride has no detectable effect on adrenal steroidogenesis, other than that which can be explained by inhibition of the 5 alpha-reductase enzyme.
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Biotransformation of the anti-angiogenic compound SU5416.
TLDR
The metabolic fate of SU5416 in microsomes from various species as well as data from in vivo biotransformation in the rat are discussed and two major metabolites ofSU5416 were identified by spectroscopic methods and comparison with authentic compounds.
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Single- and multiple-dose disposition kinetics of sunitinib malate, a multitargeted receptor tyrosine kinase inhibitor: comparative plasma kinetics in non-clinical species
TLDR
Sunitinib exhibited advantageous pharmacokinetic and dispositional properties in non-clinical species, translating into favorable properties in humans.
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