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Screening of medicinal plants from Reunion Island for antimalarial and cytotoxic activity.
TLDR
Two plants showed interesting antimalarial activity with good selectivity: Aphloia theiformis and Terminalia bentzoe. Expand
Antiplasmodial and cytotoxic activities of Rwandan medicinal plants used in the treatment of malaria.
TLDR
This study revealed for the first time the antiplasmodial activity of two plants: Terminalia mollis and Rumex abyssinicus. Expand
Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties.
TLDR
Dicoma tomentosa (Asteraceae) and Psorospermum senegalense (Clusiaceae) appeared to be the best candidates for further investigation of their antiplasmodial properties, reported for the first time by this study. Expand
The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells.
TLDR
Direct evidence is provided that DNA is the primary target of cryptolepine and it is suggested that this alkaloid is a valid candidate for the development of tumor active compounds. Expand
A HPTLC densitometric determination of flavonoids from Passiflora alata, P. edulis, P. incarnata and P. caerulea and comparison with HPLC method.
TLDR
A high-performance thin layer chromatographic (HPTLC) method was developed and employed to analyse commercial samples to illustrate their application in qualitative ('fingerprint') and quantitative determination, demonstrating their feasibility in the quality control of flavonoids from crude Passiflora drugs and phytomedicines. Expand
In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine.
TLDR
Three plants showed a very interesting antiplasmodial activity (Anisopappus chinensis, Physalis angulata and Strychnos icaja) and one of them showed a good selectivity index (>10, Anisopappa chinensis). Expand
Anti-plasmodial activity of Dicoma tomentosa (Asteraceae) and identification of urospermal A-15-O-acetate as the main active compound
TLDR
The present study highlighted the very promising anti-plasmodial activity of D. tomentosa and enabled to identify its main active compound, urospermal A-15-O-acetate, which is found to be the main cytotoxic compound of the plant. Expand
Antioxidant and Antiradical Activities of Manihot esculenta Crantz (Euphorbiaceae) Leaves and Other Selected Tropical Green Vegetables Investigated on Lipoperoxidation and
TLDR
This work investigated the capacity of aqueous extracts prepared from those vegetables to inhibit the peroxidation of a linoleic acid emulsion and identified the presence of some polyphenolic compounds, which explains at least partially the inhibitions observed in models. Expand
Discovery of a natural thiamine adenine nucleotide.
TLDR
The first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP is discovered in Escherichia coli and it is found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. Expand
In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C.
TLDR
The antimalarial properties of Tithonia diversifolia, an Asteraceae traditionally used to treat malaria, were investigated in vitro against three strains of Plasmodium falciparum, demonstrating good antiplasmodial activity and cytotoxic properties. Expand
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