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Multidrug Efflux Pumps in Staphylococcus aureus: an Update
The current knowledge on MDR efflux pumps and their intricate regulatory network in Staphylococcus aureus, a major pathogen, responsible from mild to life-threatening infections is reviewed and particular emphasis is given to the potential role that S. a Aureus MDRefflux pumps, either chromosomal or plasmid-encoded, have on resistance towards different antimicrobial agents and on the selection of drug - resistant strains. Expand
Antibiotic Stress, Genetic Response and Altered Permeability of E. coli
This study demonstrates that, in addition to the transcriptional regulation of genes coding for membrane proteins, the post-translational regulation of proteins involved in the permeability of Gram-negative bacteria also plays a major role in the physiological adaptation to antibiotic exposure. Expand
Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis.
The efflux pump activity of M. avium wild-type strain is characterized through an automated fluorometric method and correlated it with intrinsic resistance to antibiotics, indicating that intrinsic resistance is affected by EPIs such as thioridazine or chlorpromazine, an effect that might be important in research and development of new, more effective antimycobacterial therapies. Expand
Inducement and Reversal of Tetracycline Resistance in Escherichia coli K-12 and Expression of Proton Gradient-Dependent Multidrug Efflux Pump Genes
ABSTRACT Expression of eight transporter genes of Escherichia coli K-12 and its ΔacrAB mutant prior to and after induction of both strains to tetracycline resistance and after reversal of inducedExpand
Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gram-negative bacteria.
The description of the responsible efflux mechanism at its structural and physiological level will make it possible to develop along intelligent lines an improved new generation of EPIs that can readily be added to the armamentarium of current and past "fallen by the wayside" antibiotic therapies. Expand
Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis
Results support the hypothesis that activity of efflux pumps allows the maintenance of an isoniazid resistant population in a sub-optimally treated patient and should be considered in the development of new therapeutic strategies for preventing the emergence of MDR-TB during treatment. Expand
Clinical Concentrations of Thioridazine Kill Intracellular Multidrug-Resistant Mycobacterium tuberculosis
TZ appears to be a serious candidate for the management of a freshly diagnosed infection of pulmonary tuberculosis or as an adjunct to conventional antituberculosis therapy if the patient originates from an area known to have a high prevalence of multidrug-resistant M. tuberculosis isolates. Expand
Geraniol Restores Antibiotic Activities against Multidrug-Resistant Isolates from Gram-Negative Species
The essential oil of Helichrysum italicum significantly reduces the multidrug resistance of Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii and increases the efficacy of β-lactams, quinolones, and chloramphenicol. Expand
Antibacterial properties of compounds isolated from Carpobrotus edulis.
Oleanolic acid presented high antibacterial activity against a large number of bacterial strains and triterpene uvaol was the most active compound for modulation of efflux activity by MDR Gram-positive strains. Expand
Inhibition of quorum‐sensing signals by essential oils
The role of quorum sensing is well known in microbial pathogenicity and antibiotic resistance, and the inhibition of QS signals reduces the problem of resistance and virulence. Expand