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Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology.
TLDR
This report begins with a brief summary of the panel’s recommendations, followed by a more detailed analysis of its methodology, the findings of the comprehensive literature review, and a full presentation of the recommendations. Expand
Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial
TLDR
Romiplostim was well tolerated, and increased and maintained platelet counts in splenectomised and non-splenECTomised patients with ITP and treatment safety was good. Expand
Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and
Definitions in Hemophilia - Recommendation of the Scientific Subcommittee on Factor VIII and Factor IX of the Scientific and Standardization Committee of the International Society on Thrombosis andExpand
A – Biochemistry and Physiology
A longitudinal study of orthopaedic outcomes for severe factor‐VIII‐deficient haemophiliacs
TLDR
It is hypothesized that no direct relationship exists between increasing factor dosage and orthopaedic outcomes over time and optimal therapeutic regimens for persons with haemophilia are established. Expand
AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP.
TLDR
AMG 531 caused no major adverse events and increased platelet counts in patients with ITP, and increases in the platelet count were dose-dependent. Expand
A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia.
TLDR
The findings not only demonstrate that the risk of AIDS is related directly to age but also suggest that older adults are disproportionately affected during the earlier phases of HIV disease, that adolescents may have a low replication rate of HIV, and that children and adolescents may tolerate severe immunodeficiency better because they have fewer other infections or because of some unmeasured, age-dependent cofactor or immune alteration in the later phase of HIV Disease. Expand
Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study.
TLDR
The HIV- 1 RNA level during early chronic HIV-1 infection is a strong, age-independent predictor of clinical outcome; low levels define persons with a high probability of long-term AIDS-free survival. Expand
A randomized trial of avatrombopag, an investigational thrombopoietin-receptor agonist, in persistent and chronic immune thrombocytopenia.
TLDR
Avatrombopag was active and generally well tolerated, with PC response rates and AE incidence comparable with other TPO-RAs. Expand
Intravenous Anti-D Treatment of Immune Thrombocytopenic Purpura: Experience in 272 Patients
TLDR
Intervention of intravenous anti-D therapy in 261 non-splenectomized patients treated at the New York Hospital-Cornell Medical Center over the period from 1987 to 1994 is reported, finding that HIV+ patients show no adverse effects on hemoglobin decrease or HIV disease progression. Expand
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