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Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein
TLDR
ITZ is identified as a broad-spectrum inhibitor of enteroviruses and it is demonstrated that ITZ inhibits viral RNA replication by targeting oxysterol-binding protein (OSBP) and OSBP-related protein 4 (ORP4). Expand
Caveolin-1 overexpression correlates with tumour progression markers in pancreatic ductal adenocarcinoma
TLDR
The inclusion of Cav-1 in a putative panel of biomarkers predicting pancreatic cancer aggressiveness is warranted because of its association with tumor size, grade and stage and overexpression in tumors. Expand
Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome
TLDR
The recent knowledge regarding the relationship between inflammation and CKD is summarized, highlighting the current proteomic approaches, as well as the inflammasomes and gut microbiota dysbiosis involvement in the setting of CKD, culminating with the troubling bidirectional connection between CKD and renal malignancy. Expand
Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus
TLDR
It is shown that cardioviruses manipulate another PI4K, namely the ER-localized phosphatidylinositol 4-kinase III alpha (PI4KA), to generate PI4P-enriched ROs, highlighting the convergent recruitment by distantly related (+)RNA viruses of a host lipid-modifying pathway underlying formation of viral replication sites. Expand
Cholesterol shuttling is important for RNA replication of coxsackievirus B3 and encephalomyocarditis virus
TLDR
The importance of cholesterol homeostasis for efficient replication of CVB3 and EMCV is demonstrated, showing the importance of endosomal cholesterol shuttling for the replication of these viruses. Expand
Angiogenesis in cutaneous T-cell lymphoma - proteomic approaches
TLDR
In conclusion, anti-angiogenic therapeutic protocols can target tumor vasculature or malignant tumor cells directly or through a large number of combinations with other drugs. Expand
Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP.
TLDR
Investigation of the antiviral activity of the natural compound OSW-1, a ligand of OSBP that is under investigation as an anti-cancer drug finds that it inhibited the replication of all enteroviruses tested, acted at the genome replication stage and was effective in all tested cell types of three different species. Expand
Correlation of XMAP and ELISA cytokine profiles; development and validation for immunotoxicological studies in vitro.
TLDR
Quantitative differences between absolute values for IL-1beta and IL-2 obtained by xMAP and ELISA assays are found, but the relative values are comparable and the two methods keep similar trends in similar exposure conditions. Expand
Structure‐activity relationship study of itraconazole, a broad‐range inhibitor of picornavirus replication that targets oxysterol‐binding protein (OSBP)
TLDR
The data show that several pharmacological activities of ITZ can be uncoupled, which is a critical step in the development of ITz‐based antiviral compounds with greater specificity and reduced off‐target effects. Expand
Multiplex Cytokine Profiling in whole blood from individuals occupationally exposed to particulate coal species
TLDR
Exposure to coal dustand ash at work can be considered potential etiological factor for respiratory diseases of the subjects investigated and may aggravate the existing dysfunctions of the biochemical and functional parameters of the exposed persons, arterial blood pressure, dyslipidemia, excess of serum creatinin, urea and uric acid. Expand
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