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Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells
TLDR
Data indicates that conjugation of FLV to TAT (optimized formula) significantly enhances anti-proliferative activity and uptake by HepG2 cells when compared to raw FLV.
Noncyanogenic Cyanoglucoside Cyclooxygenase Inhibitors from Simmondsia chinensis.
TLDR
Two new noncyanogenic cyanoglucoside dimers, simmonosides A and B (1 and 2), were identified from the aqueous extract of jojoba (Simmondsia chinensis) leaves, representing novel dimerization patterns at α,β-unsaturated carbons of a nitrile group in 1 and γ,δ-uns saturated carbons in 2.
Phenolic compounds of Heliotropium europaeum and their biological activities
Background: Heliotropium europaeum L. is known to contain pyrrolizidine alkaloids and possesses a wide variety of biological activities. Objective: The objective of the study was to discover
Novel polycyclic pyrroloquinazoline alkaloids from Anisotes trisulcus and their biological activity
TLDR
To the authors' knowledge, anisulcusines A and B are the first polycyclic pyrroloquinazoline alkaloids that possess a unique N-methyl-1,2-dihydro-1'H-spiro[benzo[d][1,3]oxazine moiety.
Biotechnological and Ecological Potential of Micromonospora provocatoris sp. nov., a Gifted Strain Isolated from the Challenger Deep of the Mariana Trench
TLDR
Analysis of the genome sequence of strain MT25T revealed genes predicted to responsible for its adaptation to extreme environmental conditions that prevail in deep-sea sediments, including one responsible for the biosynthesis of desferrioxamine B.
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