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Guselkumab for the Treatment of Psoriasis: A Review of Phase III Trials
IntroductionInterleukin (IL)-23 inhibitors are a new class of biologics currently undergoing clinical trials for the treatment of moderate-to-severe psoriasis. Phase III studies of guselkumab, anExpand
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Neural responsivity to food cues in fasted and fed states pre and post gastric bypass surgery
Reductions in mesolimbic responsivity have been noted following Roux-en-Y gastric bypass (RYGB; Ochner et al., 2011a). Given potential for postoperative increases in postprandial gut (satiety)Expand
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Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization
BackgroundPsoriasis impacts 1–3% of the world’s population and is characterized by hyper-proliferation of keratinocytes and increased inflammation. At the molecular level, psoriasis is commonlyExpand
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The Role of the Skin and Gut Microbiome in Psoriatic Disease
Purpose of ReviewTo understand the changes in the microbiome in psoriatic disease, we conducted a systematic review of studies comparing the skin and gut microbiota in psoriatic individuals andExpand
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Diagnosis and management of peristomal pyoderma gangrenosum: A systematic review
Background: Peristomal pyoderma gangrenosum (PPG) is an uncommon subtype of pyoderma gangrenosum. PPG is a challenging condition to diagnose and treat; no evidence‐based guidelines exist. Objective:Expand
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Association of ethnicity, Fitzpatrick skin type, and hirsutism: A retrospective cross-sectional study of women with polycystic ovarian syndrome☆☆☆
Background The complex interplay between ethnicity, Fitzpatrick skin type (FST), and hirsutism in patients with polycystic ovarian syndrome (PCOS) is poorly understood. Objective In thisExpand
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Dietary Behaviors in Psoriasis: Patient-Reported Outcomes from a U.S. National Survey
IntroductionPsoriasis patients demonstrate high interest in the role of diet on their skin condition. However, data are lacking to describe dietary interventions among psoriasis patients andExpand
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RNA-seq and flow-cytometry of conventional, scalp, and palmoplantar psoriasis reveal shared and distinct molecular pathways
It has long been recognized that anatomic location is an important feature for defining distinct subtypes of plaque psoriasis. However, little is known about the molecular differences between scalp,Expand
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Monoclonal antibodies inhibiting IL-12, -23, and -17 for the treatment of psoriasis
ABSTRACT Psoriasis is a chronic, inflammatory, immune-mediated skin condition that affects 3 to 4% of the adult US population, characterized by well-demarcated, erythematous plaques with silverExpand
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The metabolomics of psoriatic disease
Metabolomics is an emerging new “omics” field involving the systematic analysis of the metabolites in a biologic system. These metabolites provide a molecular snapshot of cellular activity and areExpand
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